Molecular aspects of vertebrate retinal development

Samuel Shao Min Zhang, Xin Yuan Fu, Colin J. Barnstable

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The formation of retina from neural plate has been mapped extensively by anatomical and molecular methods. The major cascades of transcription factor expression have been identified, and deficits resulting from transcription factor knockouts are well characterized. There is extensive cross-regulation, both positive and negative, at the transcriptional level between transcription factors and this is vital in the formation of neural compartments. Many transcription factors are important at both early stages of optic cup formation and later stages of terminal differentiation of retinal cell types. The transcription factor cascades can be regulated by extrinsic factors, and some of the intracellular signaling pathways whereby this is achieved have been identified. Defining the quantitative interactions between regulatory molecules will be the next step in understanding this excellent model of vertebrate central nervous system “CNS” development.

Original languageEnglish (US)
Pages (from-to)137-152
Number of pages16
JournalMolecular Neurobiology
Volume26
Issue number2-3
DOIs
StatePublished - Jan 1 2002

Keywords

  • Neurogenesis
  • Optic cup
  • Optic vesicle
  • Photoreceptor
  • Transcription factor

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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    Zhang, S. S. M., Fu, X. Y., & Barnstable, C. J. (2002). Molecular aspects of vertebrate retinal development. Molecular Neurobiology, 26(2-3), 137-152. https://doi.org/10.1385/MN:26:2-3:137