Molecular biology of androgen action: Perspectives on neuroprotective and neurotherapeutic effects

K. N. Fargo, T. R. Pak, E. M. Foecking, K. J. Jones

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In this chapter, the molecular actions of androgens in the nervous system are summarized, with particular emphasis on the relevance of the consequences of androgen effects to neural injury and repair. Following the introduction in the first section, the second section provides background information on androgen synthesis and metabolism. The third section discusses the classical role of the androgen receptor as a transcription factor. The fourth section describes post-translational modifications of histone proteins and the androgen receptor that are required for androgen-dependent gene expression. The fifth section focuses on emerging evidence for nongenomic effects of androgens in the nervous system. The last two sections place these molecular actions of androgens in the context of neural injury and disease, and provide a discussion of the neurotherapeutic efficacy and potential translational value of androgens in neurological situations.

Original languageEnglish (US)
Title of host publicationHormones, Brain and Behavior Online
PublisherElsevier Inc.
Pages1219-1246
Number of pages28
ISBN (Print)9780080887838
DOIs
StatePublished - Jan 1 2009

Keywords

  • 5α-Reductase
  • Androgens
  • Dihydrotestosterone
  • Motoneurons
  • Neuroendocrinology
  • Neuroprotection
  • Nongenomic steroid effects
  • Nuclear receptors
  • Peripheral nerve injury
  • Regeneration
  • Steroids
  • Testosterone

ASJC Scopus subject areas

  • Neuroscience(all)

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    Fargo, K. N., Pak, T. R., Foecking, E. M., & Jones, K. J. (2009). Molecular biology of androgen action: Perspectives on neuroprotective and neurotherapeutic effects. In Hormones, Brain and Behavior Online (pp. 1219-1246). Elsevier Inc.. https://doi.org/10.1016/B978-008088783-8.00036-X