Molecular biology of bone metastasis

Lauren A. Kingsley, Pierrick G J Fournier, John Chirgwin, Theresa Guise

Research output: Contribution to journalArticle

285 Citations (Scopus)

Abstract

Metastasis is a final stage of tumor progression. Breast and prostate cancer cells preferentially metastasize to bone, wherein they cause incurable osteolytic and osteoblastic lesions. The bone matrix is rich in factors, such as transforming growth factor-β and insulin-like growth factors, which are released into the tumor microenvironment by osteolysis. These factors stimulate the growth of tumor cells and alter their phenotype, thus promoting a vicious cycle of metastasis and bone pathology. Physical factors within the bone microenvironment, including low oxygen levels, acidic pH, and high extracellular calcium concentrations, may also enhance tumor growth. These elements of the microenvironment are potential targets for chemotherapeutic intervention to halt tumor growth and suppress bone metastasis.

Original languageEnglish (US)
Pages (from-to)2609-2617
Number of pages9
JournalMolecular Cancer Therapeutics
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

Fingerprint

Molecular Biology
Neoplasm Metastasis
Bone and Bones
Neoplasms
Osteolysis
Bone Matrix
Tumor Microenvironment
Bone Development
Transforming Growth Factors
Somatomedins
Prostatic Neoplasms
Intercellular Signaling Peptides and Proteins
Pathology
Breast Neoplasms
Oxygen
Calcium
Phenotype
Growth

ASJC Scopus subject areas

  • Oncology
  • Drug Discovery
  • Pharmacology

Cite this

Molecular biology of bone metastasis. / Kingsley, Lauren A.; Fournier, Pierrick G J; Chirgwin, John; Guise, Theresa.

In: Molecular Cancer Therapeutics, Vol. 6, No. 10, 01.10.2007, p. 2609-2617.

Research output: Contribution to journalArticle

Kingsley, Lauren A. ; Fournier, Pierrick G J ; Chirgwin, John ; Guise, Theresa. / Molecular biology of bone metastasis. In: Molecular Cancer Therapeutics. 2007 ; Vol. 6, No. 10. pp. 2609-2617.
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