Molekularbiologie beim Pankreascarcinom

Uberexpression von Fibroblast Growth Factors.

Translated title of the contribution: Molecular biology of pancreatic cancer: overexpression of fibroblast growth factors

H. Friess, Murray Korc, M. W. Büchler

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the present study, the expression of a acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 were analyzed in 60 pancreatic cancer samples using Northern blot analysis, immunoblotting, in situ hybridization and immunohistochemical techniques. aFGF, bFGF and FGFR-1 were present in 63%, 55% and 52% of the tumor samples, respectively. Twenty-seven of the 60 pancreatic cancer tissue samples exhibited coexpression of aFGF and bFGF. In contrast, 14 of the tumor samples did not show immunoreactivity for aFGF or bFGF in the tumor cells. The expression of aFGF in the tumor cells had no influence on the postoperative survival period, whereas patients whose tumors were positive for bFGF and/or FGF-receptor-1 had significantly shorter postoperative survival periods. Our results suggest that bFGF and FGFR-1 may play a role in the growth behavior of pancreatic cancer and may contribute to tumor aggressiveness.

Original languageGerman
Pages (from-to)604-610
Number of pages7
JournalChirurg
Volume65
Issue number7
StatePublished - Jul 1994
Externally publishedYes

Fingerprint

Fibroblast Growth Factor 1
Fibroblast Growth Factors
Pancreatic Neoplasms
Molecular Biology
Fibroblast Growth Factor 2
Neoplasms
Postoperative Period
Receptor, Fibroblast Growth Factor, Type 1
Fibroblast Growth Factor Receptors
Survival
Immunoblotting
Northern Blotting
In Situ Hybridization

ASJC Scopus subject areas

  • Surgery

Cite this

Friess, H., Korc, M., & Büchler, M. W. (1994). Molekularbiologie beim Pankreascarcinom: Uberexpression von Fibroblast Growth Factors. Chirurg, 65(7), 604-610.

Molekularbiologie beim Pankreascarcinom : Uberexpression von Fibroblast Growth Factors. / Friess, H.; Korc, Murray; Büchler, M. W.

In: Chirurg, Vol. 65, No. 7, 07.1994, p. 604-610.

Research output: Contribution to journalArticle

Friess, H, Korc, M & Büchler, MW 1994, 'Molekularbiologie beim Pankreascarcinom: Uberexpression von Fibroblast Growth Factors.', Chirurg, vol. 65, no. 7, pp. 604-610.
Friess, H. ; Korc, Murray ; Büchler, M. W. / Molekularbiologie beim Pankreascarcinom : Uberexpression von Fibroblast Growth Factors. In: Chirurg. 1994 ; Vol. 65, No. 7. pp. 604-610.
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