Molecular biology of the VEGF and the VEGF receptor family

Research output: Contribution to journalReview article

142 Scopus citations

Abstract

Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor, specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor. Finally, the production and activation of factors involved in the coagulation/fibrinolytlc system provide further evidence for the hypothesis that processes of hemostasis are involved in angiogenesis.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalSeminars in Thrombosis and Hemostasis
Volume26
Issue number5
StatePublished - Dec 27 2000
Externally publishedYes

Keywords

  • Angiogenesis
  • Hemostasis
  • Homologues
  • Signaling
  • VEGF
  • VEGF receptors

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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