Molecular cardiology: New avenues for the diagnosis and treatment of cardiovascular disease

David R. Hathaway, Keith L. March

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

This review summarizes some of the major advances in the investigation of molecular mechanisms underlying both normal and abnormal cardiovascular function. Four major areas are highlighted including cardiac muscle, the blood vessel, atherosclerosis and thrombosis/thrombolysis. The remarkable strides in understanding multifactorial diseases such as atherosclerosis, and the development of innovative new therapies such as the use of thrombolytic agents produced by recombinant deoxyribonucleic acid (DNA) technology, are noted. Moreover, it is concluded that the past decade of basic research has provided a solid framework for improvements in the diagnosis and therapy of other forms of cardiovascular disease as well. An evaluation of current trends in basic cardiovascular research suggests that diagnostic and therapeutic approaches to disease will increasingly target specific molecular processes underlyinh the pathophysiologic state.

Original languageEnglish (US)
Pages (from-to)265-282
Number of pages18
JournalJournal of the American College of Cardiology
Volume13
Issue number2
DOIs
StatePublished - Feb 1989

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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