Molecular Events in B Lymphocyte Activation: Consequences of Signals Transduced through MHC Class II Molecules

Arthur R. Baluyut, Karen Pollok, Subbarao Bondada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Evidence is presented to demonstrate that murine B lymphocytes receive growth stimulatory signals from their surface class II molecules. Monoclonal anti-la antibodies enhanced anti-μ-induced B cell proliferative response. The signals through surface immunoglobulin (Ig) and Ia appeared to act sequentially since preexposure to anti-μ was required to observe anti-la-induced increase in B cell proliferation. Anti-Ia antibodies did not increase the number of B cells entering the G1 phase of cell cycle but always enhanced transition from G1 into the S phase in response to stimulation with anti-μ. Analysis of early gene expression revealed that signaling through class II molecules led to an increase in anti-μ-induced expression of c-myc, a proto-oncogene, and of ornithine decarboxylase, a key enzyme in polyamine biosynthesis that has been shown to be intimately related to increased cell proliferation.

Original languageEnglish (US)
Pages (from-to)353-366
Number of pages14
JournalCellular Immunology
Volume147
Issue number2
DOIs
StatePublished - Apr 1 1993
Externally publishedYes

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Lymphocyte Activation
B-Lymphocytes
Anti-Idiotypic Antibodies
Cell Proliferation
B-Cell Antigen Receptors
myc Genes
Ornithine Decarboxylase
Polyamines
G1 Phase
S Phase
Cell Cycle
Monoclonal Antibodies
Gene Expression
Enzymes
Growth

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Molecular Events in B Lymphocyte Activation : Consequences of Signals Transduced through MHC Class II Molecules. / Baluyut, Arthur R.; Pollok, Karen; Bondada, Subbarao.

In: Cellular Immunology, Vol. 147, No. 2, 01.04.1993, p. 353-366.

Research output: Contribution to journalArticle

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