Molecular evidence supporting the precursor nature of atypical adenomatous hyperplasia of the prostate

Liang Cheng, Rodolfo Montironi, Darrell Davidson, Mingsheng Wang, Antonio Lopez-Beltran, Shaobo Zhang

Research output: Contribution to journalArticle

Abstract

Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. In this study, we investigate telomere shortening in AAH (n = 93), high-grade prostatic intraepithelial neoplasia (HGPIN) (n = 68), and prostatic adenocarcinoma (PCA) (n = 70) using quantitative fluorescence in situ hybridization. Twenty percent (19 of 93) of AAH specimens, 68% (46 of 68) of HGPIN, and 83% (58 of 70) of PCA showed significant telomere shortening. Thirty-two percent of AAH lesions had α-methylacyl-CoA racemase (AMACR) expression, a sensitive and specific marker for HGPIN and PCA. AMACR expression in AAH was seen more frequently in AAH foci with telomere shortening or coexisting PCA. Our findings indicate that a subset of AAH lesions have telomere shortening and AMACR expression, suggesting that these foci may be precursors for PCA.

Original languageEnglish (US)
Pages (from-to)1272-1278
Number of pages7
JournalMolecular Carcinogenesis
Volume58
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Hyperplasia
Prostate
Telomere Shortening
Prostatic Intraepithelial Neoplasia
Adenocarcinoma
Racemases and Epimerases
Coenzyme A
Telomere
Fluorescence In Situ Hybridization
Prostatic Neoplasms
Epithelium

Keywords

  • atypical adenomatous hyperplasia
  • carcinogenesis
  • high-grade prostatic intraepithelial neoplasia
  • precursor/premalignant lesions
  • prostate
  • telomere

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

Cite this

Molecular evidence supporting the precursor nature of atypical adenomatous hyperplasia of the prostate. / Cheng, Liang; Montironi, Rodolfo; Davidson, Darrell; Wang, Mingsheng; Lopez-Beltran, Antonio; Zhang, Shaobo.

In: Molecular Carcinogenesis, Vol. 58, No. 7, 01.07.2019, p. 1272-1278.

Research output: Contribution to journalArticle

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