Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas

Qiu Rao, Qiu Yuan Xia, Liang Cheng, Xiao Jun Zhou

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Renal cell carcinoma (RCC) compromises multiple types and has been emerging dramatically over the recent several decades. Advances and consensus have been achieved targeting common RCCs, such as clear cell carcinoma, papillary RCC and chromophobe RCC. Nevertheless, little is known on the characteristics of several newly-identified RCCs, including clear cell (tubulo) papillary RCC, Xp11 translocation RCC, t(6;11) RCC, succinate dehydrogenase (SDH)-deficient RCC, acquired cystic disease-associated RCC, hereditary leiomyomatosis RCC syndrome-associated RCC, ALK translocation RCC, thyroid-like follicular RCC, tubulocystic RCC and hybrid oncocytic/chromophobe tumors (HOCT). In current review, we will collect available literature of these newly-described RCCs, analyze their clinical pathologic characteristics, discuss their morphologic and immunohistologic features, and finally summarize their molecular and genetic evidences. We expect this review would be beneficial for the understanding of RCCs, and eventually promote clinical management strategies.

Original languageEnglish (US)
Pages (from-to)29-49
Number of pages21
JournalChinese Journal of Cancer Research
Volume28
Issue number1
DOIs
StatePublished - Feb 1 2016

Keywords

  • Immunohistochemistry
  • Molecular genetics
  • Renal cell carcinoma (RCC)
  • Renal tumor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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