Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

Nikolaos G. Nikitakis, Monica Pentenero, Maria Georgaki, Catherine F. Poh, Douglas E. Peterson, Paul Edwards, Mark Lingen, John J. Sauk

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.

Original languageEnglish (US)
Pages (from-to)650-669
Number of pages20
JournalOral surgery, oral medicine, oral pathology and oral radiology
Volume125
Issue number6
DOIs
StatePublished - Jun 2018

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications'. Together they form a unique fingerprint.

  • Cite this