Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

Nikolaos G. Nikitakis, Monica Pentenero, Maria Georgaki, Catherine F. Poh, Douglas E. Peterson, Paul Edwards, Mark Lingen, John J. Sauk

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.

Original languageEnglish (US)
Pages (from-to)650-669
Number of pages20
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume125
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

Mouth Neoplasms
Squamous Cell Carcinoma
Biomarkers
Secondary Prevention
MicroRNAs
Research
Epigenomics
Methylation
Morbidity
Mortality
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions : Current knowledge and future implications. / Nikitakis, Nikolaos G.; Pentenero, Monica; Georgaki, Maria; Poh, Catherine F.; Peterson, Douglas E.; Edwards, Paul; Lingen, Mark; Sauk, John J.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 125, No. 6, 01.06.2018, p. 650-669.

Research output: Contribution to journalReview article

Nikitakis, Nikolaos G. ; Pentenero, Monica ; Georgaki, Maria ; Poh, Catherine F. ; Peterson, Douglas E. ; Edwards, Paul ; Lingen, Mark ; Sauk, John J. / Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions : Current knowledge and future implications. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2018 ; Vol. 125, No. 6. pp. 650-669.
@article{183b91dfa6fa489dbe26b4311cd4e257,
title = "Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications",
abstract = "Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.",
author = "Nikitakis, {Nikolaos G.} and Monica Pentenero and Maria Georgaki and Poh, {Catherine F.} and Peterson, {Douglas E.} and Paul Edwards and Mark Lingen and Sauk, {John J.}",
year = "2018",
month = "6",
day = "1",
doi = "10.1016/j.oooo.2018.03.012",
language = "English (US)",
volume = "125",
pages = "650--669",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions

T2 - Current knowledge and future implications

AU - Nikitakis, Nikolaos G.

AU - Pentenero, Monica

AU - Georgaki, Maria

AU - Poh, Catherine F.

AU - Peterson, Douglas E.

AU - Edwards, Paul

AU - Lingen, Mark

AU - Sauk, John J.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.

AB - Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.

UR - http://www.scopus.com/inward/record.url?scp=85046117874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046117874&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2018.03.012

DO - 10.1016/j.oooo.2018.03.012

M3 - Review article

C2 - 29709496

AN - SCOPUS:85046117874

VL - 125

SP - 650

EP - 669

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 6

ER -