Molecular mechanisms and treatment of bone metastasis

Gregory A. Clines, Theresa Guise

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The metastasis of cancer cells to bone alters bone architecture and mineral homeostasis. As described by the 'seed and soil' hypothesis, bone represents a fertile ground for cancer cells to flourish. A 'vicious cycle' of reciprocal bone-cancer cellular signals occurs with osteolytic (bone-resorbing) metastases, and a similar mechanism likely modulates osteoblastic (bone-forming) metastatic lesions as well. The development of targeted therapies either to block initial cancer cell chemotaxis, invasion and adhesion or to break the 'vicious cycle' is dependent on a more complete understanding of bone metastases. Although bisphosphonates delay progression of skeletal metastases, it is clear that more-effective therapies are needed. Cancer-associated bone morbidity remains a major public health problem, and to improve therapy and prevention it is important to understand the pathophysiology of the effects of cancer on bone. This review details scientific advances in this area.

Original languageEnglish (US)
Pages (from-to)1
Number of pages1
JournalExpert Reviews in Molecular Medicine
Volume10
Issue number7
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Bone
Bone Neoplasms
Neoplasm Metastasis
Bone and Bones
Therapeutics
Neoplasms
Cells
Diphosphonates
Chemotaxis
Minerals
Seeds
Homeostasis
Soil
Public Health
Morbidity
Public health
Medical problems
Seed
Adhesion
Soils

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Molecular Medicine

Cite this

Molecular mechanisms and treatment of bone metastasis. / Clines, Gregory A.; Guise, Theresa.

In: Expert Reviews in Molecular Medicine, Vol. 10, No. 7, 03.2008, p. 1.

Research output: Contribution to journalArticle

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