Molecular mechanisms of amyloid oligomers toxicity

Research output: Contribution to journalReview article

137 Citations (Scopus)

Abstract

Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role Aβ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers formation and toxicity still elusive. Here we review the evidence supporting the many molecular mechanisms proposed for amyloid oligomers toxicity and suggest that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloid oligomers.

Original languageEnglish (US)
JournalJournal of Alzheimer's Disease
Volume33
Issue numberSUPPL. 1
DOIs
StatePublished - 2013
Externally publishedYes

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Amyloid
Poisons
Amyloid Plaques
Cell Death
Research

Keywords

  • Alzheimer's disease
  • amyloid
  • amyloid oligomers
  • amyloid toxicity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Molecular mechanisms of amyloid oligomers toxicity. / Kayed, Rakez; Lasagna Reeves, Cristian.

In: Journal of Alzheimer's Disease, Vol. 33, No. SUPPL. 1, 2013.

Research output: Contribution to journalReview article

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