Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments

Xi Wu, Li Qin, Valerie Fako, Jian-Ting Zhang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Human FASN is the key enzyme required for de novo synthesis of fatty acids. Up-regulated FASN expression has been reported in various human cancers and was thought to contribute to poor prognosis and recurrence of these cancers. Studies using model cell lines have indicated the role of FASN in both intrinsic and acquired drug and radiation resistance. Recent studies suggest that FASN may play an important role in regulating gene expression such as pro-apoptotic proteins and cellular processes such as DNA repair pathways, which in turn contribute to resistance to drug and radiation-induced apoptosis. In this review, we will highlight our recent progress in understanding the mechanism of FASN-induced resistance.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalAdvances in Biological Regulation
Volume54
Issue number1
DOIs
StatePublished - 2014

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Fatty Acid Synthases
Drug Resistance
Neoplasms
Radiation
Apoptosis Regulatory Proteins
DNA Repair
Fatty Acids
Apoptosis
Gene Expression
Recurrence
Cell Line
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments. / Wu, Xi; Qin, Li; Fako, Valerie; Zhang, Jian-Ting.

In: Advances in Biological Regulation, Vol. 54, No. 1, 2014, p. 214-221.

Research output: Contribution to journalArticle

Wu, Xi ; Qin, Li ; Fako, Valerie ; Zhang, Jian-Ting. / Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments. In: Advances in Biological Regulation. 2014 ; Vol. 54, No. 1. pp. 214-221.
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