Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase

Niharika Samala, Sarah A. Tersey, Naga Chalasani, Ryan M. Anderson, Raghu Mirmira

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane-mainly arachidonic acid and linoleic acid-to produce oxidized pro-inflammatory lipid intermediates. 12-Lipoxygenase (12-LOX) has been studied extensively in setting of inflammation and insulin resistance. As insulin resistance is closely associated with development of NAFLD, the role of 12-LOX in pathogenesis of NAFLD has received increasing attention in recent years. In this review we discuss the role of 12-LOX in NAFLD pathogenesis and its potential role in emerging new therapeutics.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StateAccepted/In press - 2017

Fingerprint

Arachidonate 12-Lipoxygenase
Insulin Resistance
Lipoxygenases
Endoplasmic Reticulum Stress
Linoleic Acid
Unsaturated Fatty Acids
Arachidonic Acid
Non-alcoholic Fatty Liver Disease
Liver Diseases
Obesity
Fats
Cell Membrane
Pathology
Inflammation
Lipids
Liver
Population

Keywords

  • Fatty liver
  • Lipoxygenase
  • Non-alcoholic fatty liver disease
  • Obesity
  • Oxidative stress

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Molecular mechanisms of nonalcoholic fatty liver disease : Potential role for 12-lipoxygenase. / Samala, Niharika; Tersey, Sarah A.; Chalasani, Naga; Anderson, Ryan M.; Mirmira, Raghu.

In: Journal of Diabetes and its Complications, 2017.

Research output: Contribution to journalArticle

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