Molecular pathology of the central nervous system

Brent T. Harris, Eyas M. Hattab

Research output: Chapter in Book/Report/Conference proceedingChapter


In direct reflection of the vastly improved molecular interrogation techniques available today, we have recently witnessed an explosion of new emerging information concerning the molecular genetics of central nervous system (CNS) diseases, involving both neoplastic and neurodegenerative disorders. This has had immediate diagnostic, prognostic and predictive effects on various CNS diseases. The promise of targeted therapy against newly identified molecules acts only as an added motivation to furthering the study of these disease entities. In this chapter, we provide an overview of the most commonly encountered CNS tumors and neurodegenerative conditions with particular emphasis on the molecular alterations encountered in these entities, their potential applications and possible therapeutic targets.

Original languageEnglish (US)
Title of host publicationMolecular Surgical Pathology
PublisherSpringer New York
Number of pages49
ISBN (Print)9781461449003, 1461448999, 9781461448990
StatePublished - May 1 2014
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Harris, B. T., & Hattab, E. M. (2014). Molecular pathology of the central nervous system. In Molecular Surgical Pathology (pp. 357-405). Springer New York.