Molecular profiling - An essential technology enabling personalized medicine in breast cancer

Jiangang Liu, Shuyu Li, A. Keith Dunker, Vladimir N. Uversky

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Breast cancer is the most common non-cutaneous cancer diagnosed in women in the United States and the second most common cause of cancer-related mortality. Over the past two decades, the progress in screening and adjuvant systemic therapies noticeably improved the survival rate. However, traditional methods of characterizing tumors are imprecise and create heterogeneous groupings of tumors and patients. As a result, despite the important medical advances in diagnosis and treatment of breast cancer, one-third of the patients with initial breast tumor have recurrence of the disease 10 years after the diagnosis. Therefore, novel tools for discovery of strong prognostic and predictive markers that can be used to identify patients at high risk for relapse and aid in the selection of the most appropriate therapy are needed. This review analyzes some recent achievements in the development of such tools.

Original languageEnglish (US)
Pages (from-to)541-554
Number of pages14
JournalCurrent Drug Targets
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2012

Keywords

  • Biomarker
  • Breast cancer
  • Gene signature
  • Intrinsically disordered protein
  • Molecular profiling
  • Personalized medicine
  • Prognostic factor
  • Protein-protein interaction

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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