Molecular regulation of osteoclast activity

Angela Bruzzaniti, Roland Baron

Research output: Contribution to journalReview article

108 Scopus citations

Abstract

Osteoclasts are multinucleated cells derived from hematopoietic precursors that are primarily responsible for the degradation of mineralized bone during bone development, homeostasis and repair. In various skeletal disorders such as osteoporosis, hypercalcemia of malignancy, tumor metastases and Paget's disease, bone resorption by osteoclasts exceeds bone formation by osteoblasts leading to decreased bone mass, skeletal fragility and bone fracture. The overall rate of osteoclastic bone resorption is regulated either at the level of differentiation of osteoclasts from their monocytic/macrophage precursor pool or through the regulation of key functional proteins whose specific activities in the mature osteoclast control its attachment, migration and resorption. Thus, reducing osteoclast numbers and/or decreasing the bone resorbing activity of osteoclasts are two common therapeutic approaches for the treatment of hyper-resorptive skeletal diseases. In this review, several of the key functional players involved in the regulation of osteoclast activity will be discussed.

Original languageEnglish (US)
Pages (from-to)123-139
Number of pages17
JournalReviews in Endocrine and Metabolic Disorders
Volume7
Issue number1-2
DOIs
StatePublished - Jun 1 2006

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Keywords

  • Cytoskeleton
  • Integrins
  • Osteoclast
  • Podosome
  • Resorption
  • Signaling
  • Src

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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