Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening

Giorgio Gorini, Richard Bell, R. Dayne Mayfield

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment. Advances in the fields of genomics and proteomics offer a number of possible targets for the development of new therapeutic approaches. This brain-focused review highlights studies identifying neurobiological systems associated with these targets and possible pharmacotherapies, summarizing evidence from clinically relevant animal and human studies, as well as sketching improvements and challenges facing the fields of proteomics and genomics. Concluding thoughts on using results from these profiling technologies for medication development are also presented.

Original languageEnglish
Pages (from-to)293-347
Number of pages55
JournalProgress in Molecular Biology and Translational Science
Volume98
Issue numberC
DOIs
StatePublished - 2011

Fingerprint

Translational Medical Research
Health Services Research
Alcohols
Genomics
Drug Therapy
Proteomics
Alcoholism
Research
Alcohol Drinking
Therapeutics
Biomarkers
Pharmacology
Psychology
Technology
Brain

Keywords

  • Alcohol
  • Animal models
  • Behavior
  • Biomarkers
  • Complex trait disorders
  • Dependence
  • Drug development
  • Gene expression
  • Phenotype
  • Proteomics

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Molecular targets of alcohol action : Translational research for pharmacotherapy development and screening. / Gorini, Giorgio; Bell, Richard; Mayfield, R. Dayne.

In: Progress in Molecular Biology and Translational Science, Vol. 98, No. C, 2011, p. 293-347.

Research output: Contribution to journalArticle

@article{c64e7f15096e42179139a37732d45600,
title = "Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening",
abstract = "Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment. Advances in the fields of genomics and proteomics offer a number of possible targets for the development of new therapeutic approaches. This brain-focused review highlights studies identifying neurobiological systems associated with these targets and possible pharmacotherapies, summarizing evidence from clinically relevant animal and human studies, as well as sketching improvements and challenges facing the fields of proteomics and genomics. Concluding thoughts on using results from these profiling technologies for medication development are also presented.",
keywords = "Alcohol, Animal models, Behavior, Biomarkers, Complex trait disorders, Dependence, Drug development, Gene expression, Phenotype, Proteomics",
author = "Giorgio Gorini and Richard Bell and Mayfield, {R. Dayne}",
year = "2011",
doi = "10.1016/B978-0-12-385506-0.00007-7",
language = "English",
volume = "98",
pages = "293--347",
journal = "Progress in Molecular Biology and Translational Science",
issn = "1877-1173",
publisher = "Academic Press Inc.",
number = "C",

}

TY - JOUR

T1 - Molecular targets of alcohol action

T2 - Translational research for pharmacotherapy development and screening

AU - Gorini, Giorgio

AU - Bell, Richard

AU - Mayfield, R. Dayne

PY - 2011

Y1 - 2011

N2 - Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment. Advances in the fields of genomics and proteomics offer a number of possible targets for the development of new therapeutic approaches. This brain-focused review highlights studies identifying neurobiological systems associated with these targets and possible pharmacotherapies, summarizing evidence from clinically relevant animal and human studies, as well as sketching improvements and challenges facing the fields of proteomics and genomics. Concluding thoughts on using results from these profiling technologies for medication development are also presented.

AB - Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment. Advances in the fields of genomics and proteomics offer a number of possible targets for the development of new therapeutic approaches. This brain-focused review highlights studies identifying neurobiological systems associated with these targets and possible pharmacotherapies, summarizing evidence from clinically relevant animal and human studies, as well as sketching improvements and challenges facing the fields of proteomics and genomics. Concluding thoughts on using results from these profiling technologies for medication development are also presented.

KW - Alcohol

KW - Animal models

KW - Behavior

KW - Biomarkers

KW - Complex trait disorders

KW - Dependence

KW - Drug development

KW - Gene expression

KW - Phenotype

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=78650897821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650897821&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-385506-0.00007-7

DO - 10.1016/B978-0-12-385506-0.00007-7

M3 - Article

C2 - 21199775

AN - SCOPUS:78650897821

VL - 98

SP - 293

EP - 347

JO - Progress in Molecular Biology and Translational Science

JF - Progress in Molecular Biology and Translational Science

SN - 1877-1173

IS - C

ER -