Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening

Giorgio Gorini, Richard Bell, R. Dayne Mayfield

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment. Advances in the fields of genomics and proteomics offer a number of possible targets for the development of new therapeutic approaches. This brain-focused review highlights studies identifying neurobiological systems associated with these targets and possible pharmacotherapies, summarizing evidence from clinically relevant animal and human studies, as well as sketching improvements and challenges facing the fields of proteomics and genomics. Concluding thoughts on using results from these profiling technologies for medication development are also presented.

Original languageEnglish
Pages (from-to)293-347
Number of pages55
JournalProgress in Molecular Biology and Translational Science
Volume98
Issue numberC
DOIs
StatePublished - 2011

Keywords

  • Alcohol
  • Animal models
  • Behavior
  • Biomarkers
  • Complex trait disorders
  • Dependence
  • Drug development
  • Gene expression
  • Phenotype
  • Proteomics

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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