Monoamine oxidase type a in fibroblasts from patients with bipolar depressive illness

Xandra O. Breakefield, Earl L. Giller, John I. Nurnberger, Carmela M. Castiglione, Monte S. Buchsbaum, Elliot S. Gershon

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

No differences in levels of type A monoamine oxidase (MAO) were observed in cultured human skin fibroblasts from nine patients with bipolar depressive illness as compared to 18 age-, sex-, and race-matched controls. All cells were biopsied and cultured under parallel conditions. Fibroblasts from monozygotic twins (three sets) had levels of MAO activity that were highly concordant, indicating that levels measured in fibroblasts are genetically determined. Together these findings suggest that an inherited predisposition to bipolar depressive illness does not involve inherited variations in levels of type A MAO activity. Using a larger control population, a positive correlation was observed between age of donor and level of MAO activity. This finding demonstrates the need for age-matched control and patient groups when comparing levels of type A MAO in fibroblasts.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalPsychiatry Research
Volume2
Issue number3
DOIs
StatePublished - Jul 1980
Externally publishedYes

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Keywords

  • Age
  • affective disorder
  • cell culture
  • twins

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Breakefield, X. O., Giller, E. L., Nurnberger, J. I., Castiglione, C. M., Buchsbaum, M. S., & Gershon, E. S. (1980). Monoamine oxidase type a in fibroblasts from patients with bipolar depressive illness. Psychiatry Research, 2(3), 307-314. https://doi.org/10.1016/0165-1781(80)90022-0