Monoamine uptake inhibitors attenuate ethanol intake in alcohol-preferring (P) rats

J. M. Murphy, M. B. Waller, G. J. Gatto, W. J. McBride, L. Lumeng, T. K. Li

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110 Scopus citations

Abstract

The P line of alcohol-preferring rats drink pharmacologically significant amounts of ethanol when given free choice between a 10 percent ethanol solution and water. Serotonin (5-HT) uptake inhibitors and desipramine, a norepinephrine (NE) uptake inhibitor, were found to significantly reduce their ethanol consumption for up to 24 hours after intraperitoneal injection. To determine if this effect of 5-HT uptake inhibitors could be altered by receptor antagonists, some of which are short acting, P rats were trained to drink ethanol by free choice during scheduled availability, with ethanol being presented one hour every four hours during the light cycle. The majority of the ethanol was consumed during the first hour of availability, and the ethanol intake was significantly reduced by the 5-HT uptake inhibitors, fluoxetine and fluvoxamine. Pretreatment with antagonists for 5-HT1, 5-HT2 and α- and β-NE receptor systems failed to alter the fluvoxamine attenuation of ethanol intake. The mechanism by which 5-HT uptake inhibitors alter ethanol preference remains unclear.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalAlcohol
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1985

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Keywords

  • 5-HT receptor antagonists
  • 5-HT uptake inhibitors
  • Alcohol-preferring rats
  • Desipramine
  • Ethanol consumption
  • Fluoxetine
  • Fluvoxamine
  • LY53857
  • Methysergide
  • NE receptor antagonists
  • NE uptake inhibitor
  • Phentolamine
  • Propranolol

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Murphy, J. M., Waller, M. B., Gatto, G. J., McBride, W. J., Lumeng, L., & Li, T. K. (1985). Monoamine uptake inhibitors attenuate ethanol intake in alcohol-preferring (P) rats. Alcohol, 2(2), 349-352. https://doi.org/10.1016/0741-8329(85)90073-4