Monocyte accessory cell function in patients infected with the human immunodeficiency virus

Homer Twigg, Jonathan C. Weissler, Boris Yoffe, Edward J. Ball, Mary F. Lipscomb

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previous studies suggested that peripheral blood monocytes (Mo) from HIV-infected patients were poor accessory cells (AC), although most of these studies were limited by using autologous T cells as responders. Using allogeneic T cells from uninfected volunteers as responders, the current studies demonstrate that Mo from infected individuals were comparable to Mo from uninfected volunteers as AC in Con A and pokeweed mitogen-stimulated lymphocyte proliferation assays, but were inferior to normal Mo in stimulating a mixed leukocyte reaction. This deficiency was not explained by HIV Mo-induced suppression of lymphoproliferation or by death of responding CD4 lymphocytes induced by HIV transmission from infected Mo in 6-day MLR cultures. Mo from HIV-infected patients retained the ability to stimulate mumps-specific T cell lines in response to antigen, demonstrating that Mo from these individuals could process and display antigen on their cell surface in association with a functional DR molecule. Taken together these results suggest that Mo from HIV-infected patients (i) retain the ability to act as AC in T cell responses to mitogenic signals or to stimulate already activated antigen-specific T cells, but (ii) fail to stimulate resting and/or unprimed T cells in response to alloantigen and perhaps de novo antigen exposure. It is possible this Mo defect may have an adverse effect on the immune responsiveness of HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)436-448
Number of pages13
JournalClinical Immunology and Immunopathology
Volume59
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

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Monocytes
HIV
T-Lymphocytes
Antigens
Volunteers
Lymphocytes
Pokeweed Mitogens
Mumps
Mixed Lymphocyte Culture Test
Isoantigens
Cell Line

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Monocyte accessory cell function in patients infected with the human immunodeficiency virus. / Twigg, Homer; Weissler, Jonathan C.; Yoffe, Boris; Ball, Edward J.; Lipscomb, Mary F.

In: Clinical Immunology and Immunopathology, Vol. 59, No. 3, 1991, p. 436-448.

Research output: Contribution to journalArticle

Twigg, Homer ; Weissler, Jonathan C. ; Yoffe, Boris ; Ball, Edward J. ; Lipscomb, Mary F. / Monocyte accessory cell function in patients infected with the human immunodeficiency virus. In: Clinical Immunology and Immunopathology. 1991 ; Vol. 59, No. 3. pp. 436-448.
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