Monozygotic twins with Turner syndrome develop slipped capital femoral epiphysis on growth hormone therapy

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Abstract

Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has been associated with growth hormone therapy, as well as with Turner syndrome, but has never been described in twins with Turner syndrome. We report the first case of monozygotic twins with Turner syndrome with a 46,Xi(Xq) karyotype, both of whom developed slipped capital femoral epiphysis during growth hormone therapy. This report adds to existing reports of monozygotic twins with Turner syndrome and contributes to recognition of the potential clinical course in such patients. In addition, the association between slipped capital femoral epiphysis, growth hormone therapy, and Turner syndrome is emphasized.

Original languageEnglish
JournalPediatrics
Volume118
Issue number6
DOIs
StatePublished - Dec 2006

Fingerprint

Slipped Capital Femoral Epiphyses
Turner Syndrome
Monozygotic Twins
Growth Hormone
Therapeutics
Karyotype
Incidence

Keywords

  • Growth hormone therapy
  • Slipped capital femoral epiphysis
  • Turner syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Monozygotic twins with Turner syndrome develop slipped capital femoral epiphysis on growth hormone therapy",
abstract = "Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has been associated with growth hormone therapy, as well as with Turner syndrome, but has never been described in twins with Turner syndrome. We report the first case of monozygotic twins with Turner syndrome with a 46,Xi(Xq) karyotype, both of whom developed slipped capital femoral epiphysis during growth hormone therapy. This report adds to existing reports of monozygotic twins with Turner syndrome and contributes to recognition of the potential clinical course in such patients. In addition, the association between slipped capital femoral epiphysis, growth hormone therapy, and Turner syndrome is emphasized.",
keywords = "Growth hormone therapy, Slipped capital femoral epiphysis, Turner syndrome",
author = "Zeina Nabhan and Erica Eugster",
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AU - Nabhan, Zeina

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AB - Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has been associated with growth hormone therapy, as well as with Turner syndrome, but has never been described in twins with Turner syndrome. We report the first case of monozygotic twins with Turner syndrome with a 46,Xi(Xq) karyotype, both of whom developed slipped capital femoral epiphysis during growth hormone therapy. This report adds to existing reports of monozygotic twins with Turner syndrome and contributes to recognition of the potential clinical course in such patients. In addition, the association between slipped capital femoral epiphysis, growth hormone therapy, and Turner syndrome is emphasized.

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KW - Slipped capital femoral epiphysis

KW - Turner syndrome

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