Morphinan neuroprotection: New insight into the therapy of neurodegeneration

Wei Zhang, Jau Shyong Hong, Hyoung Chun Kim, Wanqin Zhang, Michelle L. Block

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Neuro-inflammation plays a pivotal role in numerous neurodegenerative disorders, such as Parkinson's disease (PD). Traditional anti-inflammatory drugs have limited therapeutic use because of their narrow spectrum and severe side effects after long-term use. Morphinans are a class of compounds containing the basic morphine structure. The following review will describe novel neuroprotective effects of several morphinans in multiple inflammatory disease models. The potential therapeutic utility and underlying mechanisms of morphinan neuroprotection are discussed.

Original languageEnglish (US)
Pages (from-to)271-302
Number of pages32
JournalCritical Reviews in Neurobiology
Volume16
Issue number4
DOIs
StatePublished - 2004

Keywords

  • 3-hydroxymorphinan (3-HM)
  • Astroglia
  • Dextromethorphan (DM)
  • Microglia
  • Morphinan
  • Naloxone
  • Neuro-inflammation
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology
  • Physiology (medical)

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