Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate

Robert Fallon, N. K. Ghosh, R. P. Cox

Research output: Contribution to journalArticle

Abstract

HeLa cells can be induced to undergo morphologic and biosynthetic 'differentiation' by growth in medium with sodium butyrate and certain other inhibitors of DNA synthesis. Modulations of cell phenotype include development desmosomes and tonofilaments and production of several glycopeptide trophic hormones (HCG, FSH, and LH). Mediators of these effects focus the cell population at the G1-S phase transition point.

Original languageEnglish (US)
Pages (from-to)129-143
Number of pages15
JournalBirth Defects: Original Article Series
Volume16
Issue number2
StatePublished - 1980
Externally publishedYes

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Butyric Acid
HeLa Cells
Nucleic Acid Synthesis Inhibitors
Desmosomes
Intermediate Filaments
Glycopeptides
Phase Transition
G1 Phase
S Phase
Hormones
Phenotype
Growth
Population

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

Cite this

Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate. / Fallon, Robert; Ghosh, N. K.; Cox, R. P.

In: Birth Defects: Original Article Series, Vol. 16, No. 2, 1980, p. 129-143.

Research output: Contribution to journalArticle

Fallon, Robert ; Ghosh, N. K. ; Cox, R. P. / Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate. In: Birth Defects: Original Article Series. 1980 ; Vol. 16, No. 2. pp. 129-143.
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