Morphologically distinct sustained ventricular tachycardias in coronary artery disease: Significance and surgical results

John M. Miller, Michael G. Kienzle, Alden H. Harken, Mark E. Josephson

Research output: Contribution to journalArticle

47 Scopus citations


One hundred patients with drug-refractory recurrent sustained ventricular tachycardia associated with coronary artery disease who underwent mapping-directed subendocardial resection for ventricular tachycardia were retrospectively evaluated with respect to a number of morphologically distinct tachycardias on a 12 lead electrocardiogram. Of 91 operative survivors, 18 patients had only one configuration of tachycardia, whereas 73 (81%) had multiple distinct tachycardia configurations; 36 had multiple configurations clinically. Patients with multiple clinical configurations had a longer mean HV interval (65 ± 11 versus 53 ± 10 ms, p < 0.005) and a higher failure rate of surgery alone (47 versus 25% for single clinical tachycardia, p < 0.05). The 13 patients whose multiple clinical tachycardias originated in disparate sites in the heart (> 5 cm between sites of origin) were less often cured by surgery alone than were those whose multiple tachycardias originated in the same or adjacent sites (83 versus 38% failure rate of surgery alone, p < 0.05). On the basis of mapping data, multiple configurations of ventricular tachycardia appear to originate in the same or adjacent sites in the majority of patients, although in 16% of patients with multiple tachycardias, the tachycardias originate at widely separated sites.

Original languageEnglish (US)
Pages (from-to)1073-1079
Number of pages7
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - Jan 1 1984


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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