Morphology and physiology of the McLeod erythrocyte. I. Scanning electron microscopy and electrolyte and water transport properties

W. R. Galey, Andrew Evan, P. S. van Nice, W. G. Dail, B. M. Wimer, R. A. Cooper

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The McLeod phenotype is a rare condition characterized by deficiencies in the Kell blood group antigens of erythrocytes. The present study has defined some of the morphological and physiological characteristics of these red cells. Scanning electron microscopy reveals that approximately 27% of McLeod cells are morphologically abnormal. These aberrant forms resemble the acanthocytes of abetalipoproteinemia. Incubation experiments indicate that the morphology of McLeod erythrocytes is not due to a plasma factor. Biochemical studies reveal that the lipid composition and microviscosity of these erythrocytes are normal. In addition, isotopic tracer experiments indicate that electrolyte transport is also within the normal range. However, osmotic water permeability is approximately 30% below normal. The absence of a lipid abnormality and other experimental data suggest that the abnormal morphology and reduced H 2O permeability of the McLeod erythrocyte may be due to defective membrane protein.

Original languageEnglish (US)
Pages (from-to)152-161
Number of pages10
JournalVox Sanguinis
Volume34
Issue number3
StatePublished - 1978
Externally publishedYes

Fingerprint

Electron Scanning Microscopy
Electrolytes
Erythrocytes
Water
Acanthocytes
Permeability
Abetalipoproteinemia
Lipids
Blood Group Antigens
Membrane Proteins
Reference Values
Phenotype

ASJC Scopus subject areas

  • Hematology

Cite this

Morphology and physiology of the McLeod erythrocyte. I. Scanning electron microscopy and electrolyte and water transport properties. / Galey, W. R.; Evan, Andrew; van Nice, P. S.; Dail, W. G.; Wimer, B. M.; Cooper, R. A.

In: Vox Sanguinis, Vol. 34, No. 3, 1978, p. 152-161.

Research output: Contribution to journalArticle

Galey, W. R. ; Evan, Andrew ; van Nice, P. S. ; Dail, W. G. ; Wimer, B. M. ; Cooper, R. A. / Morphology and physiology of the McLeod erythrocyte. I. Scanning electron microscopy and electrolyte and water transport properties. In: Vox Sanguinis. 1978 ; Vol. 34, No. 3. pp. 152-161.
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