Mosquito cells infected with banzi virus secrete an antiviral activity which is of viral origin

Chao Hung Lee, Robert H. Schloemer

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Culture media of Aedes albopictus cells which had been infected for 3 months with Banzi virus contain a factor of low molecular weight which inhibits the replication of Banzi virus in both mosquito cells and BHK-21 cells. This inhibition is virus specific in that the anti-Banzi viral factor has no effect on the replication of Japanese encephalitis or Eastern equine encephalitis viruses. The antiviral activity is blocked by treatment with anti-Banzi viral serum but not with anti-mosquito cellular serum. Incubation of anti-Banzi viral serum with the structural viral protein, V-1, results in a decreased ability of the serum to inactivate the inhibitory factor.

Original languageEnglish (US)
Pages (from-to)402-410
Number of pages9
JournalVirology
Volume110
Issue number2
DOIs
StatePublished - Apr 30 1981

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ASJC Scopus subject areas

  • Virology

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