Mosquito cells infected with banzi virus secrete an antiviral activity which is of viral origin

Chao-Hung Lee, Robert H. Schloemer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Culture media of Aedes albopictus cells which had been infected for 3 months with Banzi virus contain a factor of low molecular weight which inhibits the replication of Banzi virus in both mosquito cells and BHK-21 cells. This inhibition is virus specific in that the anti-Banzi viral factor has no effect on the replication of Japanese encephalitis or Eastern equine encephalitis viruses. The antiviral activity is blocked by treatment with anti-Banzi viral serum but not with anti-mosquito cellular serum. Incubation of anti-Banzi viral serum with the structural viral protein, V-1, results in a decreased ability of the serum to inactivate the inhibitory factor.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalVirology
Volume110
Issue number2
DOIs
StatePublished - Apr 30 1981

Fingerprint

Culicidae
Antiviral Agents
Viruses
Serum
Eastern equine encephalitis virus
Japanese Encephalitis
Viral Structural Proteins
Aedes
Virus Replication
Culture Media
Molecular Weight

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Mosquito cells infected with banzi virus secrete an antiviral activity which is of viral origin. / Lee, Chao-Hung; Schloemer, Robert H.

In: Virology, Vol. 110, No. 2, 30.04.1981, p. 402-410.

Research output: Contribution to journalArticle

Lee, Chao-Hung ; Schloemer, Robert H. / Mosquito cells infected with banzi virus secrete an antiviral activity which is of viral origin. In: Virology. 1981 ; Vol. 110, No. 2. pp. 402-410.
@article{a59ba3831ec14be98c8d9d6fe2556039,
title = "Mosquito cells infected with banzi virus secrete an antiviral activity which is of viral origin",
abstract = "Culture media of Aedes albopictus cells which had been infected for 3 months with Banzi virus contain a factor of low molecular weight which inhibits the replication of Banzi virus in both mosquito cells and BHK-21 cells. This inhibition is virus specific in that the anti-Banzi viral factor has no effect on the replication of Japanese encephalitis or Eastern equine encephalitis viruses. The antiviral activity is blocked by treatment with anti-Banzi viral serum but not with anti-mosquito cellular serum. Incubation of anti-Banzi viral serum with the structural viral protein, V-1, results in a decreased ability of the serum to inactivate the inhibitory factor.",
author = "Chao-Hung Lee and Schloemer, {Robert H.}",
year = "1981",
month = "4",
day = "30",
doi = "10.1016/0042-6822(81)90070-2",
language = "English",
volume = "110",
pages = "402--410",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Mosquito cells infected with banzi virus secrete an antiviral activity which is of viral origin

AU - Lee, Chao-Hung

AU - Schloemer, Robert H.

PY - 1981/4/30

Y1 - 1981/4/30

N2 - Culture media of Aedes albopictus cells which had been infected for 3 months with Banzi virus contain a factor of low molecular weight which inhibits the replication of Banzi virus in both mosquito cells and BHK-21 cells. This inhibition is virus specific in that the anti-Banzi viral factor has no effect on the replication of Japanese encephalitis or Eastern equine encephalitis viruses. The antiviral activity is blocked by treatment with anti-Banzi viral serum but not with anti-mosquito cellular serum. Incubation of anti-Banzi viral serum with the structural viral protein, V-1, results in a decreased ability of the serum to inactivate the inhibitory factor.

AB - Culture media of Aedes albopictus cells which had been infected for 3 months with Banzi virus contain a factor of low molecular weight which inhibits the replication of Banzi virus in both mosquito cells and BHK-21 cells. This inhibition is virus specific in that the anti-Banzi viral factor has no effect on the replication of Japanese encephalitis or Eastern equine encephalitis viruses. The antiviral activity is blocked by treatment with anti-Banzi viral serum but not with anti-mosquito cellular serum. Incubation of anti-Banzi viral serum with the structural viral protein, V-1, results in a decreased ability of the serum to inactivate the inhibitory factor.

UR - http://www.scopus.com/inward/record.url?scp=0019476476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019476476&partnerID=8YFLogxK

U2 - 10.1016/0042-6822(81)90070-2

DO - 10.1016/0042-6822(81)90070-2

M3 - Article

C2 - 6261449

AN - SCOPUS:0019476476

VL - 110

SP - 402

EP - 410

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -