Culture media of Aedes albopictus cells which had been infected for 3 months with Banzi virus contain a factor of low molecular weight which inhibits the replication of Banzi virus in both mosquito cells and BHK-21 cells. This inhibition is virus specific in that the anti-Banzi viral factor has no effect on the replication of Japanese encephalitis or Eastern equine encephalitis viruses. The antiviral activity is blocked by treatment with anti-Banzi viral serum but not with anti-mosquito cellular serum. Incubation of anti-Banzi viral serum with the structural viral protein, V-1, results in a decreased ability of the serum to inactivate the inhibitory factor.
ASJC Scopus subject areas