Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity: An Analysis of 32 Cases and a Comprehensive Review of the Literature

Andrew L. Folpe, Julie C. Fanburg-Smith, Steven D. Billings, Michele Bisceglia, Franco Bertoni, Justin Y. Cho, Michael J. Econs, Carrie Y. Inwards, Suzanne M. Jan De Beur, Thomas Mentzel, Elizabeth Montgomery, Michal Michal, Markku Miettinen, Stacey E. Mills, John D. Reith, John X. O'Connell, Andrew E. Rosenberg, Brian P. Rubin, Donald E. Sweet, Tuyethoa N. VinhLester E. Wold, Brett M. Wehrli, Kenneth E. White, Richard J. Zaino, Sharon W. Weiss

Research output: Contribution to journalReview article

384 Citations (Scopus)

Abstract

Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome of osteomalacia due to phosphate wasting. The phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) is an extremely rare, distinctive tumor that is frequently associated with OO. Despite its association with OO, many PMTMCTs go unrecognized because they are erroneously diagnosed as other mesenchymal tumors. Expression of fibroblast growth factor-23 (FGF-23), a recently described protein putatively implicated in renal tubular phosphate loss, has been shown in a small number of mesenchymal tumors with known OO. The clinicopathological features of 32 mesenchymal tumors either with known OO (29) or with features suggestive of PMTMCT (3) were studied. Immunohistochemistry for cytokeratin, S-100, actin, desmin, CD34, and FGF-23 was performed. The patients (13 male, 19 female) ranged from 9 to 80 years in age (median 53 years). A long history of OO was common. The cases had been originally diagnosed as PMTMCT (15), hemangiopericytoma (HPC) (3), osteosarcoma (3), giant cell tumor (2), and other (9). The tumors occurred in a variety of soft tissue (21) and bone sites (11) and ranged from 1.7 to 14 cm. Twenty-four cases were classic PMTMCT with low cellularity, myxoid change, bland spindled cells, distinctive "grungy" calcified matrix, fat, HPC-like vessels, microcysts, hemorrhage, osteoclasts, and an incomplete rim of membranous ossification. Four of these benign-appearing PMTMCTs contained osteoid-like matrix. Three other PMTMCTs were hypercellular and cytologically atypical and were considered malignant. The 3 cases without known OO were histologically identical to the typical PMTMCT. Four cases did not resemble PMTMCT: 2 sinonasal HPC, 1 conventional HPC, and 1 sclerosing osteosarcoma. Three cases expressed actin; all other markers were negative. Expression of FGF-23 was seen in 17 of 21 cases by immunohistochemistry and in 2 of 2 cases by RT-PCR. Follow-up (25 cases, 6-348 months) indicated the following: 21 alive with no evidence of disease and with normal serum chemistry, 4 alive with disease (1 malignant PMTMCT with lung metastases). We conclude that most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT. Improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other mesenchymal tumors. Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO.

Original languageEnglish (US)
Pages (from-to)1-30
Number of pages30
JournalAmerican Journal of Surgical Pathology
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Osteomalacia
Hemangiopericytoma
Neoplasms
Immunohistochemistry
Osteosarcoma
Actins
Phosphates
Oncogenic osteomalacia
Paraneoplastic Syndromes
Bone and Bones
Giant Cell Tumors
Polymerase Chain Reaction
Desmin
Osteoclasts
Keratins
Osteogenesis
Connective Tissue
Proteins
Fats
Hemorrhage

Keywords

  • Hemangiopericytoma
  • Immunohistochemistry
  • Mesenchymal tumors
  • Oncogenic osteomalacia
  • Phosphaturia
  • Sarcoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity : An Analysis of 32 Cases and a Comprehensive Review of the Literature. / Folpe, Andrew L.; Fanburg-Smith, Julie C.; Billings, Steven D.; Bisceglia, Michele; Bertoni, Franco; Cho, Justin Y.; Econs, Michael J.; Inwards, Carrie Y.; Jan De Beur, Suzanne M.; Mentzel, Thomas; Montgomery, Elizabeth; Michal, Michal; Miettinen, Markku; Mills, Stacey E.; Reith, John D.; O'Connell, John X.; Rosenberg, Andrew E.; Rubin, Brian P.; Sweet, Donald E.; Vinh, Tuyethoa N.; Wold, Lester E.; Wehrli, Brett M.; White, Kenneth E.; Zaino, Richard J.; Weiss, Sharon W.

In: American Journal of Surgical Pathology, Vol. 28, No. 1, 01.01.2004, p. 1-30.

Research output: Contribution to journalReview article

Folpe, AL, Fanburg-Smith, JC, Billings, SD, Bisceglia, M, Bertoni, F, Cho, JY, Econs, MJ, Inwards, CY, Jan De Beur, SM, Mentzel, T, Montgomery, E, Michal, M, Miettinen, M, Mills, SE, Reith, JD, O'Connell, JX, Rosenberg, AE, Rubin, BP, Sweet, DE, Vinh, TN, Wold, LE, Wehrli, BM, White, KE, Zaino, RJ & Weiss, SW 2004, 'Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity: An Analysis of 32 Cases and a Comprehensive Review of the Literature', American Journal of Surgical Pathology, vol. 28, no. 1, pp. 1-30. https://doi.org/10.1097/00000478-200401000-00001
Folpe, Andrew L. ; Fanburg-Smith, Julie C. ; Billings, Steven D. ; Bisceglia, Michele ; Bertoni, Franco ; Cho, Justin Y. ; Econs, Michael J. ; Inwards, Carrie Y. ; Jan De Beur, Suzanne M. ; Mentzel, Thomas ; Montgomery, Elizabeth ; Michal, Michal ; Miettinen, Markku ; Mills, Stacey E. ; Reith, John D. ; O'Connell, John X. ; Rosenberg, Andrew E. ; Rubin, Brian P. ; Sweet, Donald E. ; Vinh, Tuyethoa N. ; Wold, Lester E. ; Wehrli, Brett M. ; White, Kenneth E. ; Zaino, Richard J. ; Weiss, Sharon W. / Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity : An Analysis of 32 Cases and a Comprehensive Review of the Literature. In: American Journal of Surgical Pathology. 2004 ; Vol. 28, No. 1. pp. 1-30.
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abstract = "Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome of osteomalacia due to phosphate wasting. The phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) is an extremely rare, distinctive tumor that is frequently associated with OO. Despite its association with OO, many PMTMCTs go unrecognized because they are erroneously diagnosed as other mesenchymal tumors. Expression of fibroblast growth factor-23 (FGF-23), a recently described protein putatively implicated in renal tubular phosphate loss, has been shown in a small number of mesenchymal tumors with known OO. The clinicopathological features of 32 mesenchymal tumors either with known OO (29) or with features suggestive of PMTMCT (3) were studied. Immunohistochemistry for cytokeratin, S-100, actin, desmin, CD34, and FGF-23 was performed. The patients (13 male, 19 female) ranged from 9 to 80 years in age (median 53 years). A long history of OO was common. The cases had been originally diagnosed as PMTMCT (15), hemangiopericytoma (HPC) (3), osteosarcoma (3), giant cell tumor (2), and other (9). The tumors occurred in a variety of soft tissue (21) and bone sites (11) and ranged from 1.7 to 14 cm. Twenty-four cases were classic PMTMCT with low cellularity, myxoid change, bland spindled cells, distinctive {"}grungy{"} calcified matrix, fat, HPC-like vessels, microcysts, hemorrhage, osteoclasts, and an incomplete rim of membranous ossification. Four of these benign-appearing PMTMCTs contained osteoid-like matrix. Three other PMTMCTs were hypercellular and cytologically atypical and were considered malignant. The 3 cases without known OO were histologically identical to the typical PMTMCT. Four cases did not resemble PMTMCT: 2 sinonasal HPC, 1 conventional HPC, and 1 sclerosing osteosarcoma. Three cases expressed actin; all other markers were negative. Expression of FGF-23 was seen in 17 of 21 cases by immunohistochemistry and in 2 of 2 cases by RT-PCR. Follow-up (25 cases, 6-348 months) indicated the following: 21 alive with no evidence of disease and with normal serum chemistry, 4 alive with disease (1 malignant PMTMCT with lung metastases). We conclude that most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT. Improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other mesenchymal tumors. Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO.",
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T1 - Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity

T2 - An Analysis of 32 Cases and a Comprehensive Review of the Literature

AU - Folpe, Andrew L.

AU - Fanburg-Smith, Julie C.

AU - Billings, Steven D.

AU - Bisceglia, Michele

AU - Bertoni, Franco

AU - Cho, Justin Y.

AU - Econs, Michael J.

AU - Inwards, Carrie Y.

AU - Jan De Beur, Suzanne M.

AU - Mentzel, Thomas

AU - Montgomery, Elizabeth

AU - Michal, Michal

AU - Miettinen, Markku

AU - Mills, Stacey E.

AU - Reith, John D.

AU - O'Connell, John X.

AU - Rosenberg, Andrew E.

AU - Rubin, Brian P.

AU - Sweet, Donald E.

AU - Vinh, Tuyethoa N.

AU - Wold, Lester E.

AU - Wehrli, Brett M.

AU - White, Kenneth E.

AU - Zaino, Richard J.

AU - Weiss, Sharon W.

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N2 - Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome of osteomalacia due to phosphate wasting. The phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) is an extremely rare, distinctive tumor that is frequently associated with OO. Despite its association with OO, many PMTMCTs go unrecognized because they are erroneously diagnosed as other mesenchymal tumors. Expression of fibroblast growth factor-23 (FGF-23), a recently described protein putatively implicated in renal tubular phosphate loss, has been shown in a small number of mesenchymal tumors with known OO. The clinicopathological features of 32 mesenchymal tumors either with known OO (29) or with features suggestive of PMTMCT (3) were studied. Immunohistochemistry for cytokeratin, S-100, actin, desmin, CD34, and FGF-23 was performed. The patients (13 male, 19 female) ranged from 9 to 80 years in age (median 53 years). A long history of OO was common. The cases had been originally diagnosed as PMTMCT (15), hemangiopericytoma (HPC) (3), osteosarcoma (3), giant cell tumor (2), and other (9). The tumors occurred in a variety of soft tissue (21) and bone sites (11) and ranged from 1.7 to 14 cm. Twenty-four cases were classic PMTMCT with low cellularity, myxoid change, bland spindled cells, distinctive "grungy" calcified matrix, fat, HPC-like vessels, microcysts, hemorrhage, osteoclasts, and an incomplete rim of membranous ossification. Four of these benign-appearing PMTMCTs contained osteoid-like matrix. Three other PMTMCTs were hypercellular and cytologically atypical and were considered malignant. The 3 cases without known OO were histologically identical to the typical PMTMCT. Four cases did not resemble PMTMCT: 2 sinonasal HPC, 1 conventional HPC, and 1 sclerosing osteosarcoma. Three cases expressed actin; all other markers were negative. Expression of FGF-23 was seen in 17 of 21 cases by immunohistochemistry and in 2 of 2 cases by RT-PCR. Follow-up (25 cases, 6-348 months) indicated the following: 21 alive with no evidence of disease and with normal serum chemistry, 4 alive with disease (1 malignant PMTMCT with lung metastases). We conclude that most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT. Improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other mesenchymal tumors. Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO.

AB - Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome of osteomalacia due to phosphate wasting. The phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) is an extremely rare, distinctive tumor that is frequently associated with OO. Despite its association with OO, many PMTMCTs go unrecognized because they are erroneously diagnosed as other mesenchymal tumors. Expression of fibroblast growth factor-23 (FGF-23), a recently described protein putatively implicated in renal tubular phosphate loss, has been shown in a small number of mesenchymal tumors with known OO. The clinicopathological features of 32 mesenchymal tumors either with known OO (29) or with features suggestive of PMTMCT (3) were studied. Immunohistochemistry for cytokeratin, S-100, actin, desmin, CD34, and FGF-23 was performed. The patients (13 male, 19 female) ranged from 9 to 80 years in age (median 53 years). A long history of OO was common. The cases had been originally diagnosed as PMTMCT (15), hemangiopericytoma (HPC) (3), osteosarcoma (3), giant cell tumor (2), and other (9). The tumors occurred in a variety of soft tissue (21) and bone sites (11) and ranged from 1.7 to 14 cm. Twenty-four cases were classic PMTMCT with low cellularity, myxoid change, bland spindled cells, distinctive "grungy" calcified matrix, fat, HPC-like vessels, microcysts, hemorrhage, osteoclasts, and an incomplete rim of membranous ossification. Four of these benign-appearing PMTMCTs contained osteoid-like matrix. Three other PMTMCTs were hypercellular and cytologically atypical and were considered malignant. The 3 cases without known OO were histologically identical to the typical PMTMCT. Four cases did not resemble PMTMCT: 2 sinonasal HPC, 1 conventional HPC, and 1 sclerosing osteosarcoma. Three cases expressed actin; all other markers were negative. Expression of FGF-23 was seen in 17 of 21 cases by immunohistochemistry and in 2 of 2 cases by RT-PCR. Follow-up (25 cases, 6-348 months) indicated the following: 21 alive with no evidence of disease and with normal serum chemistry, 4 alive with disease (1 malignant PMTMCT with lung metastases). We conclude that most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT. Improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other mesenchymal tumors. Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO.

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KW - Immunohistochemistry

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KW - Oncogenic osteomalacia

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KW - Sarcoma

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