Mother rotors and the mechanisms of D600-induced type 2 ventricular fibrillation

Tsu Juey Wu, Shien-Fong Lin, Ali Baher, Zhilin Qu, Alan Garfinkel, James N. Weiss, Chih Tai Ting, Peng-Sheng Chen

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background - Two types of ventricular fibrillation (VF) have been demonstrated in isolated rabbit hearts during D600 infusion. Type 1 VF is characterized by the presence of multiple, wandering wavelets, whereas type 2 VF shows local spatiotemporal periodicity. We hypothesized that a single mother rotor underlies type 2 VF. Methods and Results - One (protocol I) or 2 (protocol II) cameras were used to map the epicardial ventricular activations in Langendorff-perfused rabbit hearts. Multiple episodes of type 2 VF were induced in 22 hearts by high-concentration (≥2.5 mg/L) D600 (protocol I). During type 2 VF, a single spiral wave (n = 19) and/or an epicardial breakthrough pattern (n = 11) was present in 14 hearts. These spiral waves either slowly drifted or intermittently anchored on the papillary muscle (PM) of the left ventricle. Dominant-frequency (DF) analyses showed that the highest local DF was near the PM (12.5±1.1 Hz). There was an excellent correlation between the highest local DF of these spiral waves and breakthroughs (11.8±1.7 Hz) and the DF of simultaneously obtained global pseudo-ECG (11.2±1.8 Hz, r=0.97, P

Original languageEnglish (US)
Pages (from-to)2110-2118
Number of pages9
JournalCirculation
Volume110
Issue number15
DOIs
StatePublished - Oct 12 2004
Externally publishedYes

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Gallopamil
Ventricular Fibrillation
Papillary Muscles
Rabbits
Periodicity
Heart Ventricles
Electrocardiography

Keywords

  • Arrhythmia
  • Fibrillation
  • Mapping
  • Ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mother rotors and the mechanisms of D600-induced type 2 ventricular fibrillation. / Wu, Tsu Juey; Lin, Shien-Fong; Baher, Ali; Qu, Zhilin; Garfinkel, Alan; Weiss, James N.; Ting, Chih Tai; Chen, Peng-Sheng.

In: Circulation, Vol. 110, No. 15, 12.10.2004, p. 2110-2118.

Research output: Contribution to journalArticle

Wu, Tsu Juey ; Lin, Shien-Fong ; Baher, Ali ; Qu, Zhilin ; Garfinkel, Alan ; Weiss, James N. ; Ting, Chih Tai ; Chen, Peng-Sheng. / Mother rotors and the mechanisms of D600-induced type 2 ventricular fibrillation. In: Circulation. 2004 ; Vol. 110, No. 15. pp. 2110-2118.
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