Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule

L. Kloetzer, W. D. Chey, R. W. McCallum, K. L. Koch, John Wo, M. Sitrin, L. A. Katz, J. M. Lackner, H. P. Parkman, G. E. Wilding, J. R. Semler, W. L. Hasler, B. Kuo

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background The wireless motility capsule (WMC) measures intraluminal pH and pressure, and records transit time and contractile activity throughout the gastrointestinal tract. Our hypothesis is that WMC can differentiate antroduodenal pressure profiles between healthy people and patients with upper gut motility dysfunctions. This study aims to analyze differences in the phasic pressure profiles of the stomach and small intestine in healthy and gastroparetic subjects. Methods Data from 71 healthy and 42 gastroparetic subjects were analyzed. The number of contractions (Ct), area under the pressure curve and motility index (MI = Ln (Ct *sum amplitudes +1)) were analyzed for 60 min before gastric emptying of the capsule (GET), (gastric window) and after GET (small bowel window) and results between groups were compared with the Wilcoxon rank sum test. Key Results Significant differences were observed between healthy and gastroparetic subjects for Ct and MI (P <0.05). Median values of the motility parameters in gastric window were Ct = 72, MI = 11.83 for healthy and Ct = 47, MI = 11.12 for gastroparetics. In the small bowel, median values were Ct = 144.5, MI = 12.78 for healthy and Ct = 93, MI = 12.12 for gastroparetics. Diabetic subjects with gastroparesis showed significantly lower Ct and MI compared with healthy subjects in both gastric and small bowel windows while idiopathic gastroparetic subjects did not show significant differences. Conclusions & Inferences The WMC is able to differentiate between healthy and gastroparetic subjects based on gastric and small bowel motility profiles.

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
Volume22
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Capsules
Stomach
Healthy Volunteers
Pressure
Gastric Emptying
Nonparametric Statistics
Gastroparesis
Small Intestine
Area Under Curve
Gastrointestinal Tract

Keywords

  • Ambulatory capsule
  • Gastroparesis
  • Manometry

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. / Kloetzer, L.; Chey, W. D.; McCallum, R. W.; Koch, K. L.; Wo, John; Sitrin, M.; Katz, L. A.; Lackner, J. M.; Parkman, H. P.; Wilding, G. E.; Semler, J. R.; Hasler, W. L.; Kuo, B.

In: Neurogastroenterology and Motility, Vol. 22, No. 5, 05.2010.

Research output: Contribution to journalArticle

Kloetzer, L, Chey, WD, McCallum, RW, Koch, KL, Wo, J, Sitrin, M, Katz, LA, Lackner, JM, Parkman, HP, Wilding, GE, Semler, JR, Hasler, WL & Kuo, B 2010, 'Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule', Neurogastroenterology and Motility, vol. 22, no. 5. https://doi.org/10.1111/j.1365-2982.2010.01468.x
Kloetzer, L. ; Chey, W. D. ; McCallum, R. W. ; Koch, K. L. ; Wo, John ; Sitrin, M. ; Katz, L. A. ; Lackner, J. M. ; Parkman, H. P. ; Wilding, G. E. ; Semler, J. R. ; Hasler, W. L. ; Kuo, B. / Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. In: Neurogastroenterology and Motility. 2010 ; Vol. 22, No. 5.
@article{b7def72a49d2469ebb942a51537d9d88,
title = "Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule",
abstract = "Background The wireless motility capsule (WMC) measures intraluminal pH and pressure, and records transit time and contractile activity throughout the gastrointestinal tract. Our hypothesis is that WMC can differentiate antroduodenal pressure profiles between healthy people and patients with upper gut motility dysfunctions. This study aims to analyze differences in the phasic pressure profiles of the stomach and small intestine in healthy and gastroparetic subjects. Methods Data from 71 healthy and 42 gastroparetic subjects were analyzed. The number of contractions (Ct), area under the pressure curve and motility index (MI = Ln (Ct *sum amplitudes +1)) were analyzed for 60 min before gastric emptying of the capsule (GET), (gastric window) and after GET (small bowel window) and results between groups were compared with the Wilcoxon rank sum test. Key Results Significant differences were observed between healthy and gastroparetic subjects for Ct and MI (P <0.05). Median values of the motility parameters in gastric window were Ct = 72, MI = 11.83 for healthy and Ct = 47, MI = 11.12 for gastroparetics. In the small bowel, median values were Ct = 144.5, MI = 12.78 for healthy and Ct = 93, MI = 12.12 for gastroparetics. Diabetic subjects with gastroparesis showed significantly lower Ct and MI compared with healthy subjects in both gastric and small bowel windows while idiopathic gastroparetic subjects did not show significant differences. Conclusions & Inferences The WMC is able to differentiate between healthy and gastroparetic subjects based on gastric and small bowel motility profiles.",
keywords = "Ambulatory capsule, Gastroparesis, Manometry",
author = "L. Kloetzer and Chey, {W. D.} and McCallum, {R. W.} and Koch, {K. L.} and John Wo and M. Sitrin and Katz, {L. A.} and Lackner, {J. M.} and Parkman, {H. P.} and Wilding, {G. E.} and Semler, {J. R.} and Hasler, {W. L.} and B. Kuo",
year = "2010",
month = "5",
doi = "10.1111/j.1365-2982.2010.01468.x",
language = "English (US)",
volume = "22",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule

AU - Kloetzer, L.

AU - Chey, W. D.

AU - McCallum, R. W.

AU - Koch, K. L.

AU - Wo, John

AU - Sitrin, M.

AU - Katz, L. A.

AU - Lackner, J. M.

AU - Parkman, H. P.

AU - Wilding, G. E.

AU - Semler, J. R.

AU - Hasler, W. L.

AU - Kuo, B.

PY - 2010/5

Y1 - 2010/5

N2 - Background The wireless motility capsule (WMC) measures intraluminal pH and pressure, and records transit time and contractile activity throughout the gastrointestinal tract. Our hypothesis is that WMC can differentiate antroduodenal pressure profiles between healthy people and patients with upper gut motility dysfunctions. This study aims to analyze differences in the phasic pressure profiles of the stomach and small intestine in healthy and gastroparetic subjects. Methods Data from 71 healthy and 42 gastroparetic subjects were analyzed. The number of contractions (Ct), area under the pressure curve and motility index (MI = Ln (Ct *sum amplitudes +1)) were analyzed for 60 min before gastric emptying of the capsule (GET), (gastric window) and after GET (small bowel window) and results between groups were compared with the Wilcoxon rank sum test. Key Results Significant differences were observed between healthy and gastroparetic subjects for Ct and MI (P <0.05). Median values of the motility parameters in gastric window were Ct = 72, MI = 11.83 for healthy and Ct = 47, MI = 11.12 for gastroparetics. In the small bowel, median values were Ct = 144.5, MI = 12.78 for healthy and Ct = 93, MI = 12.12 for gastroparetics. Diabetic subjects with gastroparesis showed significantly lower Ct and MI compared with healthy subjects in both gastric and small bowel windows while idiopathic gastroparetic subjects did not show significant differences. Conclusions & Inferences The WMC is able to differentiate between healthy and gastroparetic subjects based on gastric and small bowel motility profiles.

AB - Background The wireless motility capsule (WMC) measures intraluminal pH and pressure, and records transit time and contractile activity throughout the gastrointestinal tract. Our hypothesis is that WMC can differentiate antroduodenal pressure profiles between healthy people and patients with upper gut motility dysfunctions. This study aims to analyze differences in the phasic pressure profiles of the stomach and small intestine in healthy and gastroparetic subjects. Methods Data from 71 healthy and 42 gastroparetic subjects were analyzed. The number of contractions (Ct), area under the pressure curve and motility index (MI = Ln (Ct *sum amplitudes +1)) were analyzed for 60 min before gastric emptying of the capsule (GET), (gastric window) and after GET (small bowel window) and results between groups were compared with the Wilcoxon rank sum test. Key Results Significant differences were observed between healthy and gastroparetic subjects for Ct and MI (P <0.05). Median values of the motility parameters in gastric window were Ct = 72, MI = 11.83 for healthy and Ct = 47, MI = 11.12 for gastroparetics. In the small bowel, median values were Ct = 144.5, MI = 12.78 for healthy and Ct = 93, MI = 12.12 for gastroparetics. Diabetic subjects with gastroparesis showed significantly lower Ct and MI compared with healthy subjects in both gastric and small bowel windows while idiopathic gastroparetic subjects did not show significant differences. Conclusions & Inferences The WMC is able to differentiate between healthy and gastroparetic subjects based on gastric and small bowel motility profiles.

KW - Ambulatory capsule

KW - Gastroparesis

KW - Manometry

UR - http://www.scopus.com/inward/record.url?scp=77950674426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950674426&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2982.2010.01468.x

DO - 10.1111/j.1365-2982.2010.01468.x

M3 - Article

VL - 22

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 5

ER -