Motoneuron injury and repair: New perspectives on gonadal steroids as neurotherapeutics

Julie E. Tetzlaff, Christopher B. Huppenbauer, Lisa Tanzer, Thomas D. Alexander, Kathryn J. Jones

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritin or candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.

Original languageEnglish (US)
Pages (from-to)53-64
Number of pages12
JournalJournal of Molecular Neuroscience
Volume28
Issue number1
DOIs
StatePublished - May 31 2006
Externally publishedYes

Keywords

  • Estrogen
  • Facial motoneurons
  • Hamster
  • Immortalized mouse spinal motoneurons
  • Mouse
  • Testosterone

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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