Mouse model for thoracic congenital scoliosis

Frances A. Farley, Randall T. Loder, Bonnie T. Nolan, Mark T. Dillon, Elizabeth P. Frankenburg, Niko A. Kaciroti, Joshua D. Miller, Steven A. Goldstein, Robert N. Hensinger

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

This study sought to produce a dose-response curve for acute and chronic maternal carbon monoxide (CO) exposure versus vertebral anomalies in mouse offspring and to determine the critical day of exposure. In Part I, pregnant CD-1 mice were exposed to an acute dose of CO at 9 days of gestation. A positive dose-response relationship of acute maternal CO exposure and vertebral anomalies in the offspring was produced. In Part II, pregnant females were exposed to chronic CO for the first 11 days of gestation. Chronic exposure to CO did not produce significant vertebral anomalies. In Part III, pregnant females were exposed to an acute dose of 600 ppm of CO at gestation day 8, 9, or 10. Day 9 in this mouse breed is the critical day for maternal exposure to CO. The detected anomalies were predominately in the thoracic spine.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalJournal of Pediatric Orthopaedics
Volume21
Issue number4
DOIs
StatePublished - Jan 1 2001

    Fingerprint

Keywords

  • Animal model
  • Carbon monoxide
  • Congenital scoliosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine

Cite this

Farley, F. A., Loder, R. T., Nolan, B. T., Dillon, M. T., Frankenburg, E. P., Kaciroti, N. A., Miller, J. D., Goldstein, S. A., & Hensinger, R. N. (2001). Mouse model for thoracic congenital scoliosis. Journal of Pediatric Orthopaedics, 21(4), 537-540. https://doi.org/10.1097/01241398-200107000-00023