Mouse models of COPD

Karina A. Serban, Irina Petrache

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their implementation. E-cigarettes are an emerging health concern and may also contribute to lung disease. Accordingly, approaches to study e-cigarette vapors are provided. This chapter also includes methods and tools necessary to assess lung morphologic and functional changes in animals with emphysema-like airspace enlargement.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages16
StatePublished - Jan 1 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Cigarette smoke
  • COPD
  • E-cigarette
  • Elastase
  • Emphysema
  • Mean linear intercept
  • Mouse

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Serban, K. A., & Petrache, I. (2018). Mouse models of COPD. In Methods in Molecular Biology (pp. 379-394). (Methods in Molecular Biology; Vol. 1809). Humana Press Inc..