Mouse models of COPD

Karina A. Serban, Irina Petrache

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their implementation. E-cigarettes are an emerging health concern and may also contribute to lung disease. Accordingly, approaches to study e-cigarette vapors are provided. This chapter also includes methods and tools necessary to assess lung morphologic and functional changes in animals with emphysema-like airspace enlargement.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages379-394
Number of pages16
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1809
ISSN (Print)1064-3745

Fingerprint

Emphysema
Tobacco Products
Chronic Obstructive Pulmonary Disease
Lung
Pancreatic Elastase
Smoke
Lung Diseases
Animal Models
Health
Electronic Cigarettes

Keywords

  • Cigarette smoke
  • COPD
  • E-cigarette
  • Elastase
  • Emphysema
  • Mean linear intercept
  • Mouse

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Serban, K. A., & Petrache, I. (2018). Mouse models of COPD. In Methods in Molecular Biology (pp. 379-394). (Methods in Molecular Biology; Vol. 1809). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8570-8_25

Mouse models of COPD. / Serban, Karina A.; Petrache, Irina.

Methods in Molecular Biology. Humana Press Inc., 2018. p. 379-394 (Methods in Molecular Biology; Vol. 1809).

Research output: Chapter in Book/Report/Conference proceedingChapter

Serban, KA & Petrache, I 2018, Mouse models of COPD. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1809, Humana Press Inc., pp. 379-394. https://doi.org/10.1007/978-1-4939-8570-8_25
Serban KA, Petrache I. Mouse models of COPD. In Methods in Molecular Biology. Humana Press Inc. 2018. p. 379-394. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8570-8_25
Serban, Karina A. ; Petrache, Irina. / Mouse models of COPD. Methods in Molecular Biology. Humana Press Inc., 2018. pp. 379-394 (Methods in Molecular Biology).
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