We have characterized the promoter of the mouse retinoic acid receptor α2 (mRAR-α2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-β2 promoter. Moreover, RAR-α2 and RAR-β2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-α2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (α, β, and γ) bind in vitro.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Jan 1 1991|
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