Mouse retinoic acid receptor α2 isoform is transcribed from a promoter that contains a retinoic acid response element

P. Leroy, H. Nakshatri, P. Chambon

Research output: Contribution to journalArticle

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Abstract

We have characterized the promoter of the mouse retinoic acid receptor α2 (mRAR-α2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-β2 promoter. Moreover, RAR-α2 and RAR-β2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-α2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (α, β, and γ) bind in vitro.

Original languageEnglish (US)
Pages (from-to)10138-10142
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number22
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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