Mouse retinoic acid receptor α2 isoform is transcribed from a promoter that contains a retinoic acid response element

Pierre Leroy, Harikrishna Nakshatri, Pierre Chambon

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167 Citations (Scopus)

Abstract

We have characterized the promoter of the mouse retinoic acid receptor α2 (mRAR-α2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-β2 promoter. Moreover, RAR-α2 and RAR-β2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-α2 RARE consists of two directly repeated 5′-GTTCA-3′ motifs to which all three RARs (α, β, and γ) bind in vitro.

Original languageEnglish (US)
Pages (from-to)10138-10142
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number22
StatePublished - 1991
Externally publishedYes

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Retinoic Acid Receptors
Response Elements
Tretinoin
Protein Isoforms

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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abstract = "We have characterized the promoter of the mouse retinoic acid receptor α2 (mRAR-α2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-β2 promoter. Moreover, RAR-α2 and RAR-β2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-α2 RARE consists of two directly repeated 5′-GTTCA-3′ motifs to which all three RARs (α, β, and γ) bind in vitro.",
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T1 - Mouse retinoic acid receptor α2 isoform is transcribed from a promoter that contains a retinoic acid response element

AU - Leroy, Pierre

AU - Nakshatri, Harikrishna

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N2 - We have characterized the promoter of the mouse retinoic acid receptor α2 (mRAR-α2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-β2 promoter. Moreover, RAR-α2 and RAR-β2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-α2 RARE consists of two directly repeated 5′-GTTCA-3′ motifs to which all three RARs (α, β, and γ) bind in vitro.

AB - We have characterized the promoter of the mouse retinoic acid receptor α2 (mRAR-α2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-β2 promoter. Moreover, RAR-α2 and RAR-β2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-α2 RARE consists of two directly repeated 5′-GTTCA-3′ motifs to which all three RARs (α, β, and γ) bind in vitro.

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