MR imaging of Hippel-Lindau disease

value of gadopentetate dimeglumine.

D. R. Nelson, W. T. Yuh, M. H. Waziri, T. J. Ryals, Y. Sato, S. C. Kao, Donald Hawes, R. D. Williams

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hippel-Lindau disease is an autosomal dominant disorder characterized by tumors of the central nervous system and abdominal viscera. Frequent multisystem radiologic evaluation of persons at risk is desirable. Twenty-seven patients with Hippel-Lindau disease or a family history of the disease were examined with both unenhanced and gadopentetate dimeglumine-enhanced magnetic resonance (MR) imaging to study the usefulness of the contrast medium in the evaluation of these patients. The MR studies were correlated with computed tomographic (CT) scans in seven patients and cerebral angiograms in five. Twelve patients had hemangioblastomas in the brain, and eight of these patients also had spinal cord lesions (most were multiple), well demonstrated with gadopentetate dimeglumine. Contrast-enhanced MR imaging enabled detection of more central nervous system lesions and provided better delineation than unenhanced MR imaging, CT, or angiography. In addition, four patients with multiple renal cysts seen on CT scans and unenhanced MR images had enhancing lesions that were later proved to be renal cell carcinoma at angiography and/or surgery. Four patients had cystic lesions in the pancreas that did not enhance and were later proved to be pancreatic cysts. The authors conclude that gadopentetate dimeglumine-enhanced MR imaging appears to be a useful method for evaluating and following up patients with Hippel-Lindau disease.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalJournal of magnetic resonance imaging : JMRI
Volume1
Issue number4
StatePublished - Jul 1991
Externally publishedYes

Fingerprint

von Hippel-Lindau Disease
Gadolinium DTPA
Magnetic Resonance Imaging
Angiography
Magnetic Resonance Spectroscopy
Pancreatic Cyst
Hemangioblastoma
Central Nervous System Neoplasms
Viscera
Renal Cell Carcinoma
Contrast Media
Cysts
Pancreas
Spinal Cord
Central Nervous System
Kidney
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Nelson, D. R., Yuh, W. T., Waziri, M. H., Ryals, T. J., Sato, Y., Kao, S. C., ... Williams, R. D. (1991). MR imaging of Hippel-Lindau disease: value of gadopentetate dimeglumine. Journal of magnetic resonance imaging : JMRI, 1(4), 469-476.

MR imaging of Hippel-Lindau disease : value of gadopentetate dimeglumine. / Nelson, D. R.; Yuh, W. T.; Waziri, M. H.; Ryals, T. J.; Sato, Y.; Kao, S. C.; Hawes, Donald; Williams, R. D.

In: Journal of magnetic resonance imaging : JMRI, Vol. 1, No. 4, 07.1991, p. 469-476.

Research output: Contribution to journalArticle

Nelson, DR, Yuh, WT, Waziri, MH, Ryals, TJ, Sato, Y, Kao, SC, Hawes, D & Williams, RD 1991, 'MR imaging of Hippel-Lindau disease: value of gadopentetate dimeglumine.', Journal of magnetic resonance imaging : JMRI, vol. 1, no. 4, pp. 469-476.
Nelson DR, Yuh WT, Waziri MH, Ryals TJ, Sato Y, Kao SC et al. MR imaging of Hippel-Lindau disease: value of gadopentetate dimeglumine. Journal of magnetic resonance imaging : JMRI. 1991 Jul;1(4):469-476.
Nelson, D. R. ; Yuh, W. T. ; Waziri, M. H. ; Ryals, T. J. ; Sato, Y. ; Kao, S. C. ; Hawes, Donald ; Williams, R. D. / MR imaging of Hippel-Lindau disease : value of gadopentetate dimeglumine. In: Journal of magnetic resonance imaging : JMRI. 1991 ; Vol. 1, No. 4. pp. 469-476.
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