MsFLASH participants priorities for alleviating menopausal symptoms

J. S. Carpenter, N. F. Woods, J. L. Otte, K. A. Guthrie, C. Hohensee, K. M. Newton, H. Joffe, L. Cohen, B. Sternfeld, R. J. Lau, S. D. Reed, A. Z. Lacroix

Research output: Contribution to journalArticle

20 Scopus citations


To describe self-reported menopausal symptom priorities and their association with demographics and other symptoms among participants in an intervention trial for vasomotor symptoms (VMS).Methods Cross-sectional study embedded in the MsFLASH 02 trial, a three-by-two factorial design of yoga vs. exercise vs. usual activity and omega-3-fatty acid vs. placebo. At baseline, women (n = 354) completed hot flush diaries, a card sort task to prioritize symptoms they would most like to alleviate, and standardized questionnaires.Results The most common symptom priorities were: VMS (n = 322), sleep (n = 191), concentration (n = 140), and fatigue (n = 116). In multivariate models, women who chose VMS as their top priority symptom (n = 210) reported significantly greater VMS severity (p = 0.004) and never smoking (p = 0.012), and women who chose sleep as their top priority symptom (n = 100) were more educated (p ≤ 0.001) and had worse sleep quality (p < 0.001). ROC curves identified sleep scale scores that were highly predictive of ranking sleep as a top priority symptom.Conclusions Among women entering an intervention trial for VMS and with relatively low prevalence of depression and anxiety, VMS was the priority symptom for treatment. A card sort may be a valid tool for quickly assessing symptom priorities in clinical practice and research.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
Issue number6
StatePublished - Nov 2 2015


  • Cognitive Functioning
  • Fatigue
  • Menopause
  • Sleep Disturbances
  • Symptoms
  • Vasomotor Symptoms

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'MsFLASH participants priorities for alleviating menopausal symptoms'. Together they form a unique fingerprint.

  • Cite this

    Carpenter, J. S., Woods, N. F., Otte, J. L., Guthrie, K. A., Hohensee, C., Newton, K. M., Joffe, H., Cohen, L., Sternfeld, B., Lau, R. J., Reed, S. D., & Lacroix, A. Z. (2015). MsFLASH participants priorities for alleviating menopausal symptoms. Climacteric, 18(6), 859-866.