Mucosal and enterocyte IL-6 production during sepsis and endotoxemia - Role of transcription factors and regulation by the stress response

Timothy Pritts, Eric Hungness, Quan Wang, Bruce Robb, Dan Hershko, Per Olof Hasselgren

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: Sepsis and endotoxemia are associated with increased production of interleukin-6 (IL-6) in gut mucosa. Mucosal IL-6 may regulate enterocyte acute phase protein synthesis and intestinal IgA production. In addition, increased IL-6 has been proposed to be a mechanism of loss of mucosal integrity in critical illness. The purpose of this review is to describe current knowledge of the regulation of IL-6 production in the enterocyte/mucosa during inflammation caused by sepsis and endotoxemia. Data sources: Recent publications describing the influence of sepsis, endotoxemia, and proinflammatory cytokines on mucosal/enterocyte IL-6 production. Conclusions: IL-6 production is increased in gut mucosa during sepsis and endotoxemia and in cultured enterocytes after treatment with endotoxin or proinflammatory cytokines. The IL-6 gene is regulated by multiple transcription factors, including NF-κB, AP-1, and C/EBP. Because of the multiple important biological roles of IL-6, understanding the cellular and molecular mechanisms of mucosal/enterocyte IL-6 production as well as methods to modulate IL-6 production is of clinical importance in the setting of sepsis and other critical illness.

Original languageEnglish (US)
Pages (from-to)372-383
Number of pages12
JournalAmerican Journal of Surgery
Volume183
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Endotoxemia
Enterocytes
Interleukin-6
Sepsis
Transcription Factors
Mucous Membrane
Critical Illness
Cytokines
Acute-Phase Proteins
Information Storage and Retrieval
Transcription Factor AP-1
Endotoxins
Immunoglobulin A
Inflammation

Keywords

  • Cytokines
  • Enterocytes
  • Heat shock response
  • Inflammation
  • Mucosa
  • NF-κB

ASJC Scopus subject areas

  • Surgery

Cite this

Mucosal and enterocyte IL-6 production during sepsis and endotoxemia - Role of transcription factors and regulation by the stress response. / Pritts, Timothy; Hungness, Eric; Wang, Quan; Robb, Bruce; Hershko, Dan; Hasselgren, Per Olof.

In: American Journal of Surgery, Vol. 183, No. 4, 2002, p. 372-383.

Research output: Contribution to journalArticle

Pritts, Timothy ; Hungness, Eric ; Wang, Quan ; Robb, Bruce ; Hershko, Dan ; Hasselgren, Per Olof. / Mucosal and enterocyte IL-6 production during sepsis and endotoxemia - Role of transcription factors and regulation by the stress response. In: American Journal of Surgery. 2002 ; Vol. 183, No. 4. pp. 372-383.
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AU - Hershko, Dan

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