Recently, many advances have been made in the study of sexual differentiation, including the discoveries of the gene for antimullerian hormone as well as the gene for its receptor. However, the etiology of the clinical syndrome of mullerian agenesis remains elusive. We hypothesize that activating mutations of either the antimullerian hormone gene or its receptor gene may cause mullerian duct regression in a genetic female during embryogenesis. This clinical commentary discusses the current management of the syndrome including the Abbe-McIndoe procedure, the most commonly used method of surgical correction, and the Frank vaginal dilation method, the most common nonsurgical method of correction.
ASJC Scopus subject areas
- Obstetrics and Gynecology