Multi-center N400 ERP consistency using a primed and unprimed word paradigm

Samuel Kuperman, Bernice Porjesz, Stephan Arndt, Lance Bauer, Henri Begleiter, Ted Cizadlo, Sean O'Connor, John Rohrbaugh

Research output: Contribution to journalArticle

15 Scopus citations


A word priming paradigm involving primed, unprimed, and non-word experimental conditions was used to elicit event-related potentials (ERPs) in normal, young adult males in identically equipped electrophysiology laboratories located in 6 different cities in the USA. Analyses of the average amplitude of a specified latency window containing the N400, the N400 peak amplitude, or the latency of the N400 peak amplitude found no differences among laboratory locations. The shape of the N400 ERP wave form was also found to be highly correlated across laboratory sites for each experimental condition. Comparison of the data with analogous word priming paradigms revealed similar patterns for the N400 components and response times in both the primed and unprimed experimental conditions. These findings suggest that the data from all 6 laboratory locations are consistent with each other and are congruous with those found in other N400 studies and will permit pooling of subject data for future research.

Original languageEnglish (US)
Pages (from-to)462-470
Number of pages9
JournalElectroencephalography and Clinical Neurophysiology
Issue number6
StatePublished - Jun 1995


  • Event-related potentials
  • N400
  • Response time
  • Word priming

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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