Multicenter approach to recurrent acute and chronic pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2)

David C. Whitcomb, Dhiraj Yadav, Slivka Adam, Robert H. Hawes, Randall E. Brand, Michelle A. Anderson, Mary E. Money, Peter A. Banks, Michele D. Bishop, John Baillie, Stuart Sherman, James DiSario, Frank R. Burton, Timothy B. Gardner, Stephen T. Amann, Andres Gelrud, Simon K. Lo, Mark T. DeMeo, William M. Steinberg, Michael L. KochmanBabak Etemad, Christopher E. Forsmark, Beth Elinoff, Julia B. Greer, Michael O'Connell, Janette Lamb, M. Michael Barmada

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Background: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are complex syndromes associated with numerous etiologies, clinical variables and complications. We developed the North American Pancreatitis Study 2 (NAPS2) to be sufficiently powered to understand the complex environmental, metabolic and genetic mechanisms underlying RAP and CP. Methods: Between August 2000 and September 2006, a consortium of 20 expert academic and private sites prospectively ascertained 1,000 human subjects with RAP or CP, plus 695 controls (spouse, family, friend or unrelated). Standardized questionnaires were completed by both the physicians and study subjects and blood was drawn for genomic DNA and biomarker studies. All data were double-entered into a database and systematically reviewed to minimize errors and include missing data. Results: A total of 1,000 subjects (460 RAP, 540 CP) and 695 controls who completed consent forms and questionnaires and donated blood samples comprised the final dataset. Data were organized according to diagnosis, supporting documentation, etiological classification, clinical signs and symptoms (including pain patterns and duration, and quality of life), past medical history, family history, environmental exposures (including alcohol and tobacco use), medication use and therapeutic interventions. Upon achieving the target enrollment, data were organized and classified to facilitate future analysis. The approaches, rationale and datasets are described, along with final demographic results. Conclusion: The NAPS2 consortium has successfully completed a prospective ascertainment of 1,000 subjects with RAP and CP from the USA. These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie RAP and CP.

Original languageEnglish
Pages (from-to)520-531
Number of pages12
JournalPancreatology
Volume8
Issue number4-5
DOIs
StatePublished - Oct 2008

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Chronic Pancreatitis
Pancreatitis
Medical History Taking
Consent Forms
Environmental Exposure
Tobacco Use
Therapeutic Uses
Spouses
Documentation
Signs and Symptoms
Biomarkers
Alcohols
Quality of Life
Demography
Databases
Physicians
Pain
DNA

Keywords

  • Chronic pancreatitis
  • NAPS2 United States
  • North American Pancreatitis Study 2
  • Recurrent acute pancreatitis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

Cite this

Whitcomb, D. C., Yadav, D., Adam, S., Hawes, R. H., Brand, R. E., Anderson, M. A., ... Barmada, M. M. (2008). Multicenter approach to recurrent acute and chronic pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2). Pancreatology, 8(4-5), 520-531. https://doi.org/10.1159/000152001

Multicenter approach to recurrent acute and chronic pancreatitis in the United States : The North American Pancreatitis Study 2 (NAPS2). / Whitcomb, David C.; Yadav, Dhiraj; Adam, Slivka; Hawes, Robert H.; Brand, Randall E.; Anderson, Michelle A.; Money, Mary E.; Banks, Peter A.; Bishop, Michele D.; Baillie, John; Sherman, Stuart; DiSario, James; Burton, Frank R.; Gardner, Timothy B.; Amann, Stephen T.; Gelrud, Andres; Lo, Simon K.; DeMeo, Mark T.; Steinberg, William M.; Kochman, Michael L.; Etemad, Babak; Forsmark, Christopher E.; Elinoff, Beth; Greer, Julia B.; O'Connell, Michael; Lamb, Janette; Barmada, M. Michael.

In: Pancreatology, Vol. 8, No. 4-5, 10.2008, p. 520-531.

Research output: Contribution to journalArticle

Whitcomb, DC, Yadav, D, Adam, S, Hawes, RH, Brand, RE, Anderson, MA, Money, ME, Banks, PA, Bishop, MD, Baillie, J, Sherman, S, DiSario, J, Burton, FR, Gardner, TB, Amann, ST, Gelrud, A, Lo, SK, DeMeo, MT, Steinberg, WM, Kochman, ML, Etemad, B, Forsmark, CE, Elinoff, B, Greer, JB, O'Connell, M, Lamb, J & Barmada, MM 2008, 'Multicenter approach to recurrent acute and chronic pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2)', Pancreatology, vol. 8, no. 4-5, pp. 520-531. https://doi.org/10.1159/000152001
Whitcomb, David C. ; Yadav, Dhiraj ; Adam, Slivka ; Hawes, Robert H. ; Brand, Randall E. ; Anderson, Michelle A. ; Money, Mary E. ; Banks, Peter A. ; Bishop, Michele D. ; Baillie, John ; Sherman, Stuart ; DiSario, James ; Burton, Frank R. ; Gardner, Timothy B. ; Amann, Stephen T. ; Gelrud, Andres ; Lo, Simon K. ; DeMeo, Mark T. ; Steinberg, William M. ; Kochman, Michael L. ; Etemad, Babak ; Forsmark, Christopher E. ; Elinoff, Beth ; Greer, Julia B. ; O'Connell, Michael ; Lamb, Janette ; Barmada, M. Michael. / Multicenter approach to recurrent acute and chronic pancreatitis in the United States : The North American Pancreatitis Study 2 (NAPS2). In: Pancreatology. 2008 ; Vol. 8, No. 4-5. pp. 520-531.
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abstract = "Background: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are complex syndromes associated with numerous etiologies, clinical variables and complications. We developed the North American Pancreatitis Study 2 (NAPS2) to be sufficiently powered to understand the complex environmental, metabolic and genetic mechanisms underlying RAP and CP. Methods: Between August 2000 and September 2006, a consortium of 20 expert academic and private sites prospectively ascertained 1,000 human subjects with RAP or CP, plus 695 controls (spouse, family, friend or unrelated). Standardized questionnaires were completed by both the physicians and study subjects and blood was drawn for genomic DNA and biomarker studies. All data were double-entered into a database and systematically reviewed to minimize errors and include missing data. Results: A total of 1,000 subjects (460 RAP, 540 CP) and 695 controls who completed consent forms and questionnaires and donated blood samples comprised the final dataset. Data were organized according to diagnosis, supporting documentation, etiological classification, clinical signs and symptoms (including pain patterns and duration, and quality of life), past medical history, family history, environmental exposures (including alcohol and tobacco use), medication use and therapeutic interventions. Upon achieving the target enrollment, data were organized and classified to facilitate future analysis. The approaches, rationale and datasets are described, along with final demographic results. Conclusion: The NAPS2 consortium has successfully completed a prospective ascertainment of 1,000 subjects with RAP and CP from the USA. These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie RAP and CP.",
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AU - Yadav, Dhiraj

AU - Adam, Slivka

AU - Hawes, Robert H.

AU - Brand, Randall E.

AU - Anderson, Michelle A.

AU - Money, Mary E.

AU - Banks, Peter A.

AU - Bishop, Michele D.

AU - Baillie, John

AU - Sherman, Stuart

AU - DiSario, James

AU - Burton, Frank R.

AU - Gardner, Timothy B.

AU - Amann, Stephen T.

AU - Gelrud, Andres

AU - Lo, Simon K.

AU - DeMeo, Mark T.

AU - Steinberg, William M.

AU - Kochman, Michael L.

AU - Etemad, Babak

AU - Forsmark, Christopher E.

AU - Elinoff, Beth

AU - Greer, Julia B.

AU - O'Connell, Michael

AU - Lamb, Janette

AU - Barmada, M. Michael

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N2 - Background: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are complex syndromes associated with numerous etiologies, clinical variables and complications. We developed the North American Pancreatitis Study 2 (NAPS2) to be sufficiently powered to understand the complex environmental, metabolic and genetic mechanisms underlying RAP and CP. Methods: Between August 2000 and September 2006, a consortium of 20 expert academic and private sites prospectively ascertained 1,000 human subjects with RAP or CP, plus 695 controls (spouse, family, friend or unrelated). Standardized questionnaires were completed by both the physicians and study subjects and blood was drawn for genomic DNA and biomarker studies. All data were double-entered into a database and systematically reviewed to minimize errors and include missing data. Results: A total of 1,000 subjects (460 RAP, 540 CP) and 695 controls who completed consent forms and questionnaires and donated blood samples comprised the final dataset. Data were organized according to diagnosis, supporting documentation, etiological classification, clinical signs and symptoms (including pain patterns and duration, and quality of life), past medical history, family history, environmental exposures (including alcohol and tobacco use), medication use and therapeutic interventions. Upon achieving the target enrollment, data were organized and classified to facilitate future analysis. The approaches, rationale and datasets are described, along with final demographic results. Conclusion: The NAPS2 consortium has successfully completed a prospective ascertainment of 1,000 subjects with RAP and CP from the USA. These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie RAP and CP.

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KW - Recurrent acute pancreatitis

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