Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: From discovery to clinical application

Jiye Yin, Jianting Zhang

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Multidrug resistance-associated protein 1 (MRP1/ABCC1) is the first identified member of ABCC subfamily which belongs to ATP-binding cassette ( ABC ) transporter superfamily. It is ubiquitously expressed in almost all human tissues and transports a wide spectrum of substrates including drugs, heavy metal anions, toxicants, and conjugates of glutathione, glucuronide and sulfate. With the advance of sequence technology, many MRP1/ABCC1 polymorphisms have been identified. Accumulating evidences show that some polymorphisms are significantly associated with drug resistance and disease susceptibility. In vitro reconstitution studies have also unveiled the mechanism for some polymorphisms. In this review, we present recent advances in understanding the role and mechanism of MRP1/ABCC1 polymorphisms in drug resistance, toxicity, disease susceptibility and severity, prognosis prediction, and methods to select and predict functional polymorphisms.

Original languageEnglish (US)
Pages (from-to)927-938
Number of pages12
JournalJournal of Central South University (Medical Sciences)
Volume36
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • ABCC1
  • Disease susceptibility
  • Drug resistance
  • Multidrug resistance-associated protein 1
  • Prognosis
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Medicine(all)

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