Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

Shams Halat, John Eble, David Grignon, Antonio Lopez-Beltran, Rodolfo Montironi, Puay Hoon Tan, Mingsheng Wang, Shaobo Zhang, Gregory T. MacLennan, Liang Cheng

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Multilocular cystic renal cell carcinoma is an uncommon low grade renal cell carcinoma with unique morphologic features. Its cytogenetic characteristics have not been fully investigated. Its relationship to typical clear cell renal cell carcinoma is uncertain. We evaluated 19 cases of multilocular cystic renal cell carcinoma diagnosed by strict morphologic criteria using the 2004 WHO classification system. The control group consisted of 19 low grade (Fuhrman grades 1 or 2) clear cell renal cell carcinomas. Chromosome 3p deletion status was determined by dual color interphase fluorescence in situ hybridization analysis. Chromosome 3p deletion was identified in 17 out of 19 (89%) of the clear cell renal cell carcinoma cases and 14 out of 19 (74%) of the multilocular cystic renal cell carcinoma cases, respectively. There was no difference in the status of chromosome 3p deletion between clear cell renal cell carcinoma and multilocular cystic renal cell carcinoma (P0.40). These results support the concept that multilocular cystic renal cell carcinoma as a subtype of clear cell renal cell carcinoma.

Original languageEnglish
Pages (from-to)931-936
Number of pages6
JournalModern Pathology
Volume23
Issue number7
DOIs
StatePublished - Jul 2010

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Renal Cell Carcinoma
Chromosome Deletion
Interphase
Fluorescence In Situ Hybridization
Cytogenetics
Color
Control Groups

Keywords

  • classification
  • differential diagnosis
  • fluorescent in situ hybridization (FISH)
  • Kidney
  • molecular genetics
  • multilocular cystic renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma. / Halat, Shams; Eble, John; Grignon, David; Lopez-Beltran, Antonio; Montironi, Rodolfo; Tan, Puay Hoon; Wang, Mingsheng; Zhang, Shaobo; MacLennan, Gregory T.; Cheng, Liang.

In: Modern Pathology, Vol. 23, No. 7, 07.2010, p. 931-936.

Research output: Contribution to journalArticle

Halat, Shams ; Eble, John ; Grignon, David ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Tan, Puay Hoon ; Wang, Mingsheng ; Zhang, Shaobo ; MacLennan, Gregory T. ; Cheng, Liang. / Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma. In: Modern Pathology. 2010 ; Vol. 23, No. 7. pp. 931-936.
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