Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study

Maria Rosaria Raspollini, Francesca Castiglione, Guido Martignoni, Alberto Lapini, Liang Cheng, Rodolfo Montironi, Antonio Lopez-Beltran

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We describe a rare multicentric neoplastic disease arising bilteraly in the kidney. The patient was a 70-year-old man, who, during a period of 3 years, was treated for five independent tumors of three histotypes (three multilocular cystic clear cell renal cell neoplasms of low malignant potential, one clear cell renal cell carcinoma, and one clear cell papillary renal cell carcinoma, respectively). Pathologic diagnosis of the reported tumors was confirmed by immunohistochemical analyses, including CD10, CA IX, CK7, AMACR/RACEMASE, and 34 beta E12. Molecular detection of KRAS, BRAF, NRAS, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET, and EGFR gene mutational analysis was also performed in all tumors.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalAPMIS
Volume124
Issue number7
DOIs
StatePublished - Jul 1 2016

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Keywords

  • ALK
  • BRAF
  • clear cell papillary renal cell carcinoma
  • Clear cell renal cell carcinoma
  • DDR2
  • EGFR
  • ERBB2
  • kidney
  • KRAS
  • MAP2K1
  • molecular pathology
  • multilocular cystic clear cell renal cell neoplasm of low malignant potential
  • NRAS
  • PIK3CA
  • RET

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology and Allergy

Cite this

Raspollini, M. R., Castiglione, F., Martignoni, G., Lapini, A., Cheng, L., Montironi, R., & Lopez-Beltran, A. (2016). Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study. APMIS, 124(7), 619-623. https://doi.org/10.1111/apm.12536