Multiple-breath washout as a lung function test in cystic fibrosis: A cystic fibrosis foundation workshop report

Padmaja Subbarao, Carlos Milla, Paul Aurora, Jane C. Davies, Stephanie Davis, Graham L. Hall, Sonya Heltshe, Philipp Latzin, Anders Lindblad, Jessica E. Pittman, Paul D. Robinson, Margaret Rosenfeld, Florian Singer, Tim D. Starner, Felix Ratjen, Wayne Morgan

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The lung clearance index (LCI) is a lung function parameter derived from the multiple-breath washout (MBW) test. Although first developed 60 years ago, the technique was not widely used for many years. Recent technological advances in equipment design have produced gains in popularity for this test among cystic fibrosis (CF) researchers and clinicians, particularly for testing preschool-aged children. LCI has been shown to be feasible and sensitive to early CF lung disease in patients of all ages from infancy to adulthood. A workshop was convened in January 2014 by the North American Cystic Fibrosis Foundation to determine the readiness of the LCI for use in multicenter clinical trials as well as clinical care. The workshop concluded that the MBW text is a valuable potential outcome measure for CF clinical trials in preschool-aged patients and in older patients with FEV<inf>1</inf> in the normal range. However, gaps in knowledge about the choice of device, gas, and standardization across systems are key issues precluding its use as a clinical trial end point in infants. Based on the current evidence, there are insufficient data to support the use of LCI or MBW parameters in the routine clinical management of patients with CF.

Original languageEnglish
Pages (from-to)932-939
Number of pages8
JournalAnnals of the American Thoracic Society
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Respiratory Function Tests
Cystic Fibrosis
Education
Lung
Clinical Trials
Equipment Design
Breath Tests
Preschool Children
Lung Diseases
Multicenter Studies
Reference Values
Gases
Research Personnel
Outcome Assessment (Health Care)
Equipment and Supplies

Keywords

  • Cystic fibrosis
  • Lung clearance index
  • Multiple-breath washout
  • Pulmonary function tests

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Multiple-breath washout as a lung function test in cystic fibrosis : A cystic fibrosis foundation workshop report. / Subbarao, Padmaja; Milla, Carlos; Aurora, Paul; Davies, Jane C.; Davis, Stephanie; Hall, Graham L.; Heltshe, Sonya; Latzin, Philipp; Lindblad, Anders; Pittman, Jessica E.; Robinson, Paul D.; Rosenfeld, Margaret; Singer, Florian; Starner, Tim D.; Ratjen, Felix; Morgan, Wayne.

In: Annals of the American Thoracic Society, Vol. 12, No. 6, 01.06.2015, p. 932-939.

Research output: Contribution to journalArticle

Subbarao, P, Milla, C, Aurora, P, Davies, JC, Davis, S, Hall, GL, Heltshe, S, Latzin, P, Lindblad, A, Pittman, JE, Robinson, PD, Rosenfeld, M, Singer, F, Starner, TD, Ratjen, F & Morgan, W 2015, 'Multiple-breath washout as a lung function test in cystic fibrosis: A cystic fibrosis foundation workshop report', Annals of the American Thoracic Society, vol. 12, no. 6, pp. 932-939. https://doi.org/10.1513/AnnalsATS.201501-021FR
Subbarao, Padmaja ; Milla, Carlos ; Aurora, Paul ; Davies, Jane C. ; Davis, Stephanie ; Hall, Graham L. ; Heltshe, Sonya ; Latzin, Philipp ; Lindblad, Anders ; Pittman, Jessica E. ; Robinson, Paul D. ; Rosenfeld, Margaret ; Singer, Florian ; Starner, Tim D. ; Ratjen, Felix ; Morgan, Wayne. / Multiple-breath washout as a lung function test in cystic fibrosis : A cystic fibrosis foundation workshop report. In: Annals of the American Thoracic Society. 2015 ; Vol. 12, No. 6. pp. 932-939.
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