Multiple gene action determining a mouse salivary protein phenotype: Identification of the structural gene for androgen binding protein (Abp)

Stephen R. Dlouhy, Robert C. Karn

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A novel variation in electrophoretic phenotype is described for a mouse salivary androgen binding protein (Abp). Crosses show that the variation is inherited in an autosomal codominant manner and protein characterization studies show that the variant Abp differs in isoelectric point from the common form of the protein. Those observations suggest that the variation involves the structural gene for the mouse salivary Abp. The genetic studies also show that the electrophoretic mobility of the variant Abp can be influenced by the sex-limited saliva pattern (Ssp) gene. The SspS allele alters the electrophoretic mobility of Abp in males at puberty or in females which have received exogenous testosterone [Karn, R. C., Dlouhy, S. R., Springer, K. R., Hjorth, J. P., and Nielsen, J. T. (1982). Biochem Genet. 20:493]. This study shows that Abp and Ssp are distinct genes which are not closely linked and that SspS is trans active in F1 (Abpa/Abpb, SspS/SspF) males.

Original languageEnglish (US)
Pages (from-to)657-667
Number of pages11
JournalBiochemical Genetics
Volume22
Issue number7-8
DOIs
StatePublished - Aug 1 1984

Keywords

  • androgen binding proteins
  • mouse salivary proteins
  • structural gene variation

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

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