Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics

Zhiliang Xu, Scott Christley, Joshua Lioi, Oleg Kim, Cameron Harvey, Wenzhao Sun, Elliot Rosen, Mark Alber

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through " fibrin elements" representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.

Original languageEnglish (US)
Pages (from-to)367-388
Number of pages22
JournalMethods in Cell Biology
Volume110
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Fibrin
Thrombosis
Blood Platelets
Growth
Thrombin

Keywords

  • Clot
  • Fibrin
  • Platelet
  • Rupture
  • Submodel
  • Thrombus

ASJC Scopus subject areas

  • Cell Biology

Cite this

Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics. / Xu, Zhiliang; Christley, Scott; Lioi, Joshua; Kim, Oleg; Harvey, Cameron; Sun, Wenzhao; Rosen, Elliot; Alber, Mark.

In: Methods in Cell Biology, Vol. 110, 2012, p. 367-388.

Research output: Contribution to journalArticle

Xu, Zhiliang ; Christley, Scott ; Lioi, Joshua ; Kim, Oleg ; Harvey, Cameron ; Sun, Wenzhao ; Rosen, Elliot ; Alber, Mark. / Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics. In: Methods in Cell Biology. 2012 ; Vol. 110. pp. 367-388.
@article{49c2b1af0d0d4fb38b3f54a68aab8b0e,
title = "Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics",
abstract = "A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through {"} fibrin elements{"} representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.",
keywords = "Clot, Fibrin, Platelet, Rupture, Submodel, Thrombus",
author = "Zhiliang Xu and Scott Christley and Joshua Lioi and Oleg Kim and Cameron Harvey and Wenzhao Sun and Elliot Rosen and Mark Alber",
year = "2012",
doi = "10.1016/B978-0-12-388403-9.00014-X",
language = "English (US)",
volume = "110",
pages = "367--388",
journal = "Methods in Cell Biology",
issn = "0091-679X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics

AU - Xu, Zhiliang

AU - Christley, Scott

AU - Lioi, Joshua

AU - Kim, Oleg

AU - Harvey, Cameron

AU - Sun, Wenzhao

AU - Rosen, Elliot

AU - Alber, Mark

PY - 2012

Y1 - 2012

N2 - A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through " fibrin elements" representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.

AB - A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through " fibrin elements" representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.

KW - Clot

KW - Fibrin

KW - Platelet

KW - Rupture

KW - Submodel

KW - Thrombus

UR - http://www.scopus.com/inward/record.url?scp=84859311278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859311278&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-388403-9.00014-X

DO - 10.1016/B978-0-12-388403-9.00014-X

M3 - Article

C2 - 22482956

AN - SCOPUS:84859311278

VL - 110

SP - 367

EP - 388

JO - Methods in Cell Biology

JF - Methods in Cell Biology

SN - 0091-679X

ER -