Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics

Zhiliang Xu, Scott Christley, Joshua Lioi, Oleg Kim, Cameron Harvey, Wenzhao Sun, Elliot D. Rosen, Mark Alber

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through " fibrin elements" representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.

Original languageEnglish (US)
Title of host publicationMethods in Cell Biology
PublisherAcademic Press Inc.
Pages367-388
Number of pages22
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameMethods in Cell Biology
Volume110
ISSN (Print)0091-679X

Keywords

  • Clot
  • Fibrin
  • Platelet
  • Rupture
  • Submodel
  • Thrombus

ASJC Scopus subject areas

  • Cell Biology

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