Munc18c

A controversial regulator of peripheral insulin action

Latha Ramalingam, Stephanie M. Yoder, Eunjin Oh, Debbie C. Thurmond

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Insulin resistance, a hallmark of impaired glucose tolerance and type 2 diabetes (T2D), arises from dysfunction of insulin action and subsequent glucose uptake by peripheral tissues, predominantly skeletal muscle and fat. Exocytosis of glucose transporter (GLUT4)-containing vesicles facilitated by soluble NSF (N-ethylmaleimide-sensitive factor) attachment receptor (SNARE) protein isoforms, and Munc18c (mammalian homolog of Unc-18c) mediates this glucose uptake. Emerging evidences, including recent human clinical studies, point to pivotal roles for Munc18c in peripheral insulin action in adipose and skeletal muscle. Intriguing new advances are also initiating debates regarding the molecular mechanism(s) controlling Munc18c action. The objective of this review is therefore to present a balanced perspective of new continuities and controversies surrounding the regulation and requirement for Munc18c in the regulation of peripheral insulin action.

Original languageEnglish
Pages (from-to)601-608
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume25
Issue number11
DOIs
StatePublished - 2014

Fingerprint

Insulin
Skeletal Muscle
N-Ethylmaleimide-Sensitive Proteins
Glucose
Glucose Intolerance
Facilitative Glucose Transport Proteins
Exocytosis
Type 2 Diabetes Mellitus
Insulin Resistance
Protein Isoforms
Fats
Clinical Studies

Keywords

  • Adipose
  • Glucose uptake
  • GLUT4 vesicle exocytosis
  • Skeletal muscle
  • SNARE proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Munc18c : A controversial regulator of peripheral insulin action. / Ramalingam, Latha; Yoder, Stephanie M.; Oh, Eunjin; Thurmond, Debbie C.

In: Trends in Endocrinology and Metabolism, Vol. 25, No. 11, 2014, p. 601-608.

Research output: Contribution to journalArticle

Ramalingam, Latha ; Yoder, Stephanie M. ; Oh, Eunjin ; Thurmond, Debbie C. / Munc18c : A controversial regulator of peripheral insulin action. In: Trends in Endocrinology and Metabolism. 2014 ; Vol. 25, No. 11. pp. 601-608.
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