Murine antigen H-2.7: Phenotypic conversion of erythrocytes in radiation chimeras

Chun Ming Huang, Roy W. Geib, Jan Klein

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

By use of radiation chimeras produced between H-2.7+ and H-2.7}- strains, A.SW and A.BY and B10.S(7R) and B10.S(9R), we demonstrate that the H-2.7 antigen can be passively attached to or detached from red blood cells. Thus, genetically H-2.7}- red blood cells derived from H-2.7}- bone marrow cells, gain H-2.7 antigen while maturing in the H-2.7+ host. Similarly, genetically H- 2.7+ red blood cells derived from H-2.7+ bone marrow cells become H-2.7}- while maturing in H-2.7- recipients. This behavior of the H-2.7 antigen is similar to that described for human Chido and Rodgers blood group antigens.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalImmunogenetics
Volume9
Issue number1
DOIs
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Immunology
  • Genetics

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