Murine antigen H-2.7

Phenotypic conversion of erythrocytes in radiation chimeras

Chun Ming Huang, Roy W. Geib, Jan Klein

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

By use of radiation chimeras produced between H-2.7+ and H-2.7}- strains, A.SW and A.BY and B10.S(7R) and B10.S(9R), we demonstrate that the H-2.7 antigen can be passively attached to or detached from red blood cells. Thus, genetically H-2.7}- red blood cells derived from H-2.7}- bone marrow cells, gain H-2.7 antigen while maturing in the H-2.7+ host. Similarly, genetically H- 2.7+ red blood cells derived from H-2.7+ bone marrow cells become H-2.7}- while maturing in H-2.7- recipients. This behavior of the H-2.7 antigen is similar to that described for human Chido and Rodgers blood group antigens.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalImmunogenetics
Volume9
Issue number1
DOIs
StatePublished - Dec 1979
Externally publishedYes

Fingerprint

Radiation Chimera
Erythrocytes
Bone Marrow Cells
Blood Group Antigens
H antigen

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Murine antigen H-2.7 : Phenotypic conversion of erythrocytes in radiation chimeras. / Huang, Chun Ming; Geib, Roy W.; Klein, Jan.

In: Immunogenetics, Vol. 9, No. 1, 12.1979, p. 583-589.

Research output: Contribution to journalArticle

Huang, Chun Ming ; Geib, Roy W. ; Klein, Jan. / Murine antigen H-2.7 : Phenotypic conversion of erythrocytes in radiation chimeras. In: Immunogenetics. 1979 ; Vol. 9, No. 1. pp. 583-589.
@article{ad6f9b8f000f433999e51519f65bf813,
title = "Murine antigen H-2.7: Phenotypic conversion of erythrocytes in radiation chimeras",
abstract = "By use of radiation chimeras produced between H-2.7+ and H-2.7}- strains, A.SW and A.BY and B10.S(7R) and B10.S(9R), we demonstrate that the H-2.7 antigen can be passively attached to or detached from red blood cells. Thus, genetically H-2.7}- red blood cells derived from H-2.7}- bone marrow cells, gain H-2.7 antigen while maturing in the H-2.7+ host. Similarly, genetically H- 2.7+ red blood cells derived from H-2.7+ bone marrow cells become H-2.7}- while maturing in H-2.7- recipients. This behavior of the H-2.7 antigen is similar to that described for human Chido and Rodgers blood group antigens.",
author = "Huang, {Chun Ming} and Geib, {Roy W.} and Jan Klein",
year = "1979",
month = "12",
doi = "10.1007/BF01570452",
language = "English (US)",
volume = "9",
pages = "583--589",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Murine antigen H-2.7

T2 - Phenotypic conversion of erythrocytes in radiation chimeras

AU - Huang, Chun Ming

AU - Geib, Roy W.

AU - Klein, Jan

PY - 1979/12

Y1 - 1979/12

N2 - By use of radiation chimeras produced between H-2.7+ and H-2.7}- strains, A.SW and A.BY and B10.S(7R) and B10.S(9R), we demonstrate that the H-2.7 antigen can be passively attached to or detached from red blood cells. Thus, genetically H-2.7}- red blood cells derived from H-2.7}- bone marrow cells, gain H-2.7 antigen while maturing in the H-2.7+ host. Similarly, genetically H- 2.7+ red blood cells derived from H-2.7+ bone marrow cells become H-2.7}- while maturing in H-2.7- recipients. This behavior of the H-2.7 antigen is similar to that described for human Chido and Rodgers blood group antigens.

AB - By use of radiation chimeras produced between H-2.7+ and H-2.7}- strains, A.SW and A.BY and B10.S(7R) and B10.S(9R), we demonstrate that the H-2.7 antigen can be passively attached to or detached from red blood cells. Thus, genetically H-2.7}- red blood cells derived from H-2.7}- bone marrow cells, gain H-2.7 antigen while maturing in the H-2.7+ host. Similarly, genetically H- 2.7+ red blood cells derived from H-2.7+ bone marrow cells become H-2.7}- while maturing in H-2.7- recipients. This behavior of the H-2.7 antigen is similar to that described for human Chido and Rodgers blood group antigens.

UR - http://www.scopus.com/inward/record.url?scp=0018574783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018574783&partnerID=8YFLogxK

U2 - 10.1007/BF01570452

DO - 10.1007/BF01570452

M3 - Article

VL - 9

SP - 583

EP - 589

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 1

ER -