Muscarinic cholinergic receptors on skin fibroblasts in familial affective disorder

N. S. Nadi, John Nurnberger, E. S. Gershon

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Cultured human skin fibroblasts possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist. The number of binding sites appears to be a stable characteristic of each cell line. We studied fibroblasts from 18 patients with a major affective disorder and found that they had a higher density of binding sites than cells from 12 normal controls. Fibroblasts from 18 relatives who had histories of major or minor affective disorder also had a higher density, and those from five normal relatives were similar to controls. These results, although still preliminary, suggest that increased cholinergic-receptor density may be associated with vulnerability to affective disorders in some familial cases.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalNew England Journal of Medicine
Volume311
Issue number4
StatePublished - 1984
Externally publishedYes

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Cholinergic Receptors
Muscarinic Receptors
Mood Disorders
Fibroblasts
Skin
Binding Sites
Adenylyl Cyclases
Norepinephrine
Cell Line

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Muscarinic cholinergic receptors on skin fibroblasts in familial affective disorder. / Nadi, N. S.; Nurnberger, John; Gershon, E. S.

In: New England Journal of Medicine, Vol. 311, No. 4, 1984, p. 225-230.

Research output: Contribution to journalArticle

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