Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta

Alycia G. Berman, Jason M. Organ, Matthew R. Allen, Joseph M. Wallace

Research output: Contribution to journalArticle

Abstract

Mechanical interactions between muscle and bone have long been recognized as integral to bone integrity. However, few studies have directly measured these interactions within the context of musculoskeletal disease. In this study, the osteogenesis imperfecta murine model (oim/oim) was utilized because it has both reduced bone and muscle properties, allowing direct assessment of whether weakened muscle is able to engender strain on weakened bone. To do so, a strain gauge was attached to the tibia of healthy and oim/oim mice, muscles within the posterior quadrant of the lower hind limb were stimulated, and bone strain during muscle contraction was measured. Results indicated that the relationship between maximum muscle torque and maximum engendered strain is altered in oim/oim bone, with less torque required to engender strain compare to wild-type and heterozygous mice. Maximum muscle torque at 150 Hz stimulation frequency was able to engender ~1500 μɛ in oim/oim animals. However, even though the strain engendered in the oim/oim mice was high relative to historical bone formation thresholds, the maximum strain values were still significantly lower than that of the wild-type mice. These results are promising in that they suggest that muscle stimulation may be a viable means of inducing bone formation in oim/oim and potentially other disease models where muscle weakness/atrophy exist.

Original languageEnglish (US)
Article number115061
JournalBone
Volume132
DOIs
StatePublished - Mar 2020

Fingerprint

Osteogenesis Imperfecta
Muscle Weakness
Muscle Contraction
Muscles
Bone and Bones
Torque
Osteogenesis
Musculoskeletal Diseases
Muscular Atrophy
Cortical Bone
Tibia
Lower Extremity

Keywords

  • Biomechanics
  • Bone-muscle interactions
  • Exercise
  • Osteogenesis imperfecta
  • Sarcopenia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta. / Berman, Alycia G.; Organ, Jason M.; Allen, Matthew R.; Wallace, Joseph M.

In: Bone, Vol. 132, 115061, 03.2020.

Research output: Contribution to journalArticle

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